Browsing by Author "Nastaran Ranjbari"
Now showing 1 - 10 of 10
Results Per Page
Sort Options
- ItemBenign Metastasizing Pleomorphic Adenoma: A Case Report(Brieflands, 2014-12-01) Nastaran Ranjbari; Neda Hojat PanahIntroduction: Pleomorphic adenoma (mixed tumor) is the most common neoplasm of the salivary gland. It is usually a benign, slow-growing and well-circumscribed tumor. However, there are rare reports of a subset of these tumors metastasizing to distant sites without undergoing malignant transformation. Here we describe a case of pleomorphic adenoma of the parotid gland that metastasied to the cervical lymph node coincidentally with similar appearance of the primary lesion in the ipsilateral parotid gland. Case Presentation: A 78-year-old male with right sided cervical lymph node and ipsilateral parotid mass from one year ago came to Imam Khomeini hospital. Physical examination, a painless firm mass was found within year, the parotid and lymph node of the neck concomitantly with no other organs abnormalities. A diagnosis of pleomorphic adenoma was made from completion parotidectomy and cervical lymphadenectomy. No histologic characteristic of malignancy were seen in either specimen; therefore a diagnosis of benign metastasizing mixed tumor was rendered. Discussion: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity. Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasized to distinct sites. It remains to be determined whether this benign metastasizing pleomorphic adenoma is really low grade salivary malignancy.
- ItemComparison of Hibiscus sabdariffa L. Extract and Enalapril with Regard to Their Effect on Lung Fibrosis in a Bleomycin-induced Rat Model of Lung Fibrosis(Brieflands, 2018-05-31) Ali Asghar Hemmeti; Mohammad Javad Khodayar; Alireza Malayeri; Mohammad Ali Rashidi Nooshabadi; Nastaran Ranjbari; Mohammad Reza Rashidi NooshabadiBackground: Pulmonary fibrosis is an idiopathic and chronic inflammatory interstitial lung disease that responds only weakly to available medical therapies and has a potentially fatal prognosis. Hibiscus sabdariffa L. contains several antioxidants, such as protocatechuic acid (PCA) and anthocyanins, which may be beneficial for the treatment of fibrosis. Objectives: The purpose of this study was to investigate the inhibitory effect of the H. sabdariffa L. extract (HSE) on angiotensin-converting enzyme (ACE) and compare it with that of enalapril in a rat model of bleomycin-induced pulmonary fibrosis. Methods: Female Wistar rats (weighing 180 g- 235 g) were randomly divided into seven groups (n = 8). The negative and positive control groups were intratracheally administered a single dose of saline (1 mL/kg) and bleomycin (7.5 UI/kg/mL) respectively. The treatment groups were orally administered enalapril (20 mg/kg), PCA (100 mg/kg) and HSE (100, 200, and 400 mg/kg) daily for one week before and three weeks after bleomycin administration. The animals were sacrificed 24 hours after the last administration of the therapeutic agent. The transforming growth factor-β1, platelet-derived growth factor, tumor necrosis factor-α and angiotensin II (ANG II) levels in the bronchoalveolar lavage fluid (BALF) and also the malondialdehyde (MDA) and hydroxyproline (HP) levels in lung tissue were measured. The presence of fibrosis, inflammatory cells, connective tissue and collagen deposition in the lung was microscopically evaluated using Masson’s trichrome staining. Results: The results showed a significant increase in the lung index and the levels of MDA, HP, ANG II and pro-inflammatory cytokines after bleomycin administration. Pre-treatment with enalapril, PCA and HSE resulted in a reduction in the levels of the above factors. Enalapril and HSE (400 mg/kg) treatment could mitigate the progression of fibrosis clearly via ACE blocking and a decrease in the level of oxidative stress. Enalapril, PCA and HSE could prevent the infiltration of fibroblasts, inflammatory cells and alveolar thickening caused by bleomycin. Conclusions: Our results indicate that HSE, which has demonstrated anti-hypertensive effects in herbal medicine, can be useful for the treatment of inflammatory and fibrotic disorders.
- ItemCongenital nasopharyngeal teratoma (epignathus) with airway obstruction(Brieflands, 2015-03-31) Nastaran Ranjbari; Anahita Doustkhah Vajari; Vita DerakhshandehTeratomas of the nasopharynx are rare in neonates, usually presenting in the neonatal period with frequency of the total 1 in 4000 live birth and derived from the upper jaw, palate and sphenoid bone. It usually protrudes through the mouth, leading to obstruction of the upper airway .Teratoma of the head and neck are most- ly benign neoplasm. In this article we are reporting a case of Epignathus associated with airway obstruction. A 40 day old male neonate was admitted with severe respiratory distress and nasopharyngeal mass protrude to the oral cavity prevented oral feeding. History of mild hydroaminious was positive. No other abnormali- ties were noted on physical examination. MRI of the head and neck revealed solid cystic mass with nasopharyngeal origin without intracranial extension. Mass was resected surgically and pathology revealed a mature teratoma dominantly composed of mature neuroglial elements and choroid plexus. Nasopharyngeal teratoma cases are interesting because of their obscure origin and unusual clinical presentation.surgical resection is the treatment of choice and should be done urgently in the case of airway ob- struction.
- ItemDetection and Genotyping of Human Papillomavirus in Cervical Tissue Samples in Ahvaz, Southwest Iran(Brieflands, 2013-09-01) Mojtaba Hamidi-Fard; Mojtaba Fattahi-Abdizadeh; Manoochehr Makvandi; Nastaran Ranjbari; Esrafil Mansoori; Alireza Samarbaf-ZadehBackground: 500,000 new cases with progressive cancer of cervix are reported worldwide annually. This malignant cancer is the second common cancer among females. Human papillomavirus (HPV) is considered as the major cause of cervical cancer and dysplasia. PCR Application to detect the HPV DNA in clinical specimens besides microscopic examination of cervical biopsy (Papanicolaou smear) (Pap smear) are valuable prognostic indicators in cervical cancer management. Objectives: Due to the absence of epidemiological data on prevalence and distribution of HPV genotypes in Khuzestan province, the authors decided to conduct a research to determine the HPV genotypes in cases with a degree of cervical dysplasia. Materials and Methods: In this study, 60 samples of paraffin-embedded biopsy samples archived in the library of pathology laboratory of Ahvaz Imam Khomeini hospital were selected for further experiments. After DNA extraction of each specimen, the infection of the tissue with HPV was confirmed by PCR. PCR products were sequenced to detect HPV genotypes. Results: Out of 60 cervical biopsy samples, 8 (%13.3) cases were HPV DNA positive. Four (%50) were genotype 16 positive, 2 (%25) were genotype 6 positive, 1(%12.5) sample was detected as the genotype 18 and 1 of the positive cases was genotype 11 of HPV. Conclusions: Our study shows that prevalence of HPV infection in cervical biopsy samples collected from suspected patients in Khouzestan province is slightly higher than other provinces of Iran. Since HPV cervical infection, is an indicator for the host cervical cancer progression, parallel with Pap smear test, PCR detection of HPV DNA in biopsy of suspected cases is recommended.
- ItemEvaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer(Brieflands, 2015-03-31) Nastaran Ranjbari; Neda HojatpanahBackground: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.Materials and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under- went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.Result: P53 marker was positive in 40 cases (%74). Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlated with vascular and neural invasion or involvement of margins (p≥0.05).Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua- tion of p53 level could be a useful tool in identification of patients with more aggressive disease.
- ItemHistologic Evaluation of Normobaric Oxygen Therapy Safety in an Animal Model(Brieflands, 2012-08-25) Esmaeil Idani; Nastaran Ranjbari; Farideh Sharifipour; Ali Asghar Hemmati; Mohammad MalekahmadiBackground: Oxygen therapy, as a therapeutic modality, can be used for long periods of times. However, it may be accompanied by potential complications and side effects. Objectives: To evaluate the side effects of normobaric oxygen therapy in rabbits. Materials and Methods: In a double-blind experiment, 28 white New Zealand rabbits were randomized into an oxygen treatment group (n = 14) and a control group (n = 14).The oxygen treatment group received 100% oxygen at a flow rate of 5 L/min for 1 h daily,for 1 month. The animals were euthanized at the end of the study, and following autopsya histological evaluation was carried out to detect levels of oxygen toxicity in their; lungs, liver, brain, heart, kidney, eyes and spleen. Results: Histological evaluation revealed no evidence of toxicity in the examined tissues, compared with the control group. Conclusions: Oxygen therapy at a flow rate of 5 L/min for 1 h daily for 1 month had no systemic toxicity and it appears to be safe in rabbits.
- ItemAn Investigation of Antibacterial Resistance Patterns Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates Collected from Intensive Care Units of a University-Affiliated Hospital in Ahvaz, Iran(Brieflands, 2016-08-01) Farrokh Izadpour; Nastaran Ranjbari; Mohammad-Reza Aramesh; Mojtaba Moosavian; Shiva ShahAli; Farzaneh Larki; Hamed Tabesh; Afrooz MorvaridiBackground: In recent decades, multidrug-resistant non-fermenting Gram-negative pathogens, particularly Acinetobacter baumannii and Pseudomonas aeruginosa, have been recognized as a major cause of healthcare-associated and nosocomial infections and outbreaks. Objectives: The aim of this study was to determine the prevalence and pattern of antibiotic resistance in A. baumannii and P. aeruginosa isolates collected from intensive care units (ICUs). Methods: One hundred fifty-five clinical isolates, including 80 (51.6%) isolates of A. baumannii and 75 (48.4%) isolates of P. aeruginosa, from hospitalized patients in the ICUs of a teaching hospital in Ahvaz, Iran, were collected from January 1 to December 30, 2013. The organisms were identified with conventional bacteriological methods, and antimicrobial susceptibility testing was performed on all isolates in accordance with clinical laboratory and standards institute (CLSI) guidelines. Results: The maximum resistance rates among A. baumannii isolates were observed for ciprofloxacin and trimethoprim-sulfamethoxazole (96.9% and 95.2%, respectively). For P. aeruginosa isolates, the maximum resistance rates were reported for ceftriaxone and trimethoprim-sulfamethoxazole (97.2% and 92.4%, respectively). Conclusions: The majority of A. baumannii and P. aeruginosa isolates were found to be resistant to commonly recommended antibiotics. Therefore, surveillance of antibiotic consumption and proper antibiotic administration guidelines are essential for preventing major outbreaks in the future.
- ItemPancreatic Lymphangioma as a Rare Pancreatic Mass: A Case Report(Brieflands, 2016-02-28) Abdolhasan Talaiezadeh; Nastaran Ranjbari; Mohammad BakhtiariIntroduction: Cystic lymphangiomas of abdomen has mostly involved mesentery and retro peritoneum that should be considered as a differential diagnosis of abdominal masses. Pancreatic lymphangiomas were extremely rare that should be differentiated from neoplastic pancreatic cysts. Patients have commonly presented with epigastric pain and a relevant palpable epigastric mass. Case Presentation: A 65-year-old lady who has presented with epigastric pain, then during investigations, a cystic tumor which located in the tail of pancreas, has found. Whereas definite diagnosis of tumor with routine procedures was impossible, the tumor has completely resected by distal pancreatectomy and splenectomy. Pathology and IHC was suggestive of benign lymphangioma. Conclusions: According to this presentation diagnosis of cystic lymphangioma of the tail of pancreas should be considered as a differential diagnosis of pancreatic cystic lesions and complete excision has been the treatment of choice.
- ItemThe Relationship Between Promoter Methylation of RASSF1A Gene and Prognosis of Patients Affected with Breast Cancer in Khuzestan Province(Brieflands, 2019-12-23) Javad Mohammadi Asl; Farideh Ghanbari Mardasi; Ghasem Saki; Fakher Rahim; Iran Rashidi; Nastaran Ranjbari; Parvin Kheradmand; Mohammad Abromand; Jasem ghavabesh; Kolsoum FazeliBackground: DNA methylation is one of the most frequent molecular changes that are associated with human cancers. Tumor suppressor genes are the important targets of hypermethylation in breast cancer and thus may result in cancer by deregulation of cell growth and division. Objectives: The purpose of this research was to compare the methylation pattern of the RASSF1A gene in cancerous and normal tissues. Methods: Twenty breast cancer patients with known clinicopathologic characteristics and 20 healthy women as control were studied for analysis of the methylation status of the RASSF1A gene promoter by methylation-specific polymerase chain reaction (MS-PCR) technique. Results: The findings showed that the frequency of RASSF1A promoter methylation was in 15% of tumor tissues and 5% of normal tissues. These results indicate that there is no statistically significant relationship between the RASSF1A promoter methylation status of tumor tissues and normal tissues (P > 0.05). Conclusions: Until now, the evidence for powerful methylation biomarkers is still incomplete and the recognized biomarkers require further validation.
- ItemStudy of the Association of Mutant HBsAg Gene and Hodgkin and Non-Hodgkin Lymphoma(Brieflands, 2015-11-01) Kamyar Makvandi; Nastaran Ranjbari; Manoochehr Makvandi; Ali Ashraf Teimori; Niloofar Neisi; Mojtaba Rasti; Vida Alipour; Mostafa Albokord; Malek Kanani; Ramezan Ahadi; Ala HabibianBackground: Hepatitis B Virus (HBV) is responsible for chronic, acute, and fulminant hepatitis, which are prevalent worldwide. Chronic HBV may lead to cirrhosis and hepatocellular carcinoma. Several epidemiological studies have indicated that hepatitis B virus is involved in B-cell Hodgkin and Non-Hodgkin Lymphoma (NHL). Objectives: The aim of this study was to evaluate the association between hepatitis B infection and Hodgkin and non-Hodgkin Lymphoma. Materials and Methods: Paraffin embedded of 41 block samples including 12 (29.26%) Hodgkin and 29 (70.73%) non-Hodgkin patients were collected. Next, DNA extraction was carried out for all the samples followed by HBV DNA detection by the nested polymerase chain reaction (PCR). The positive HBV DNA samples were sequenced, and HBV genotypes and HBV subtypes were determined. Results: Three out of 12 (25%) Hodgkin samples and seven out of 29 (24.13%) non-Hodgkin showed positive HBV DNA results. The results of sequencing revealed that the D genotype was predominant among the positive HBV patients. Interestingly an unpredictable amino acid proline was detected in position 88 of the HBs gene, which indicates a new mutation in the “S” region of HBV DNA in patients with Hodgkin and non-Hodgkin lymphoma. Conclusions: A high rate of 25% and 24.13% of HBV DNA was detected among patients with Hodgkin and non-Hodgkin lymphoma, respectively.