Browsing by Author "Negin Amini"
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- ItemAmeliorative effect of Artichoke (Cynara scolymus) on chemically induced arrhythmias in Rats(Brieflands, 2018-10-31) Negin Amini; Mahin DianatIntroduction: Antioxidant factors play an important role in cardiovascular diseases. Medicinal plants are considered as suitable replacement for chemical drugs. Hydro-alcoholic extract of Cynara scolymus L. (artichoke) was effective in the treatment of different diseases due to its strong antioxidant properties. This study was designed to examine the ameliorative effect of hydro-alcoholic extract of artichoke against CaCl2 induced arrhythmia in rats.Materials and methods: Male Sprague-Dawley rats (200-250 g) were divided into 5 groups: Control (saline 1 ml/kg, gavage, 21 days), Extract (100, 200, 400 mg/kg, gavage, 21 days) and Amiodarone (10 mg/kg, i.v). The rats were anesthetized and the antidysrhythmic effects induced by CaCl2 (140 mg/kg) injection was evaluated. Lead II was recorded at the first and the last days of the experimental period. Heart rate (HR), incidence rate of premature ventricular beats (PVB), ventricular fibrillation (VF) and ventricular tachycardia (VT) were calculated and the data obtained from extract groups were compared to those from the amiodarone group. Results were analyzed using one-way ANOVA and FISHER exact test. Level of statistical significance was set at P
- ItemProtective Effect of Trimetazidine on Kidney Dysfunction: A Review of Experimental Evidence(Brieflands, 2024-02-29) Negin Amini; Mohammad BadaviBackground and Objectives: Acute kidney injury is the main cause of morbidity and mortality in the worldwide that is accompanied by short-term and long-term complications, including chronic kidney disease, end-stage renal disease, and ultimately death. Various mechanisms are involved in renal dysfunction, including oxidative stress, inflammatory responses, apoptosis, fibrosis, and mitochondrial dysfunction. Trimetazidine as a drug with free radical oxygen scavenging property represents to be more invaluable against acute kidney injury. Trimetazidine is considered as an anti-ischemic drug in the treatment of cardiac diseases which has been documented pharmacologic effects such as antioxidant, anti-apoptotic, and anti-inflammatory properties in renal ischemia-reperfusion injury, diabetic nephropathy, and nephrotoxicity models.Subjects and Methods: This review underlines the nephroprotective effect of trimetazidine on kidney injury models. For this review, the articles have been searched in the databases, including PubMed, Scopus, Web of science, and Google Scholar. The search process was provided using these keywords: “Trimetazidine”, “kidney”, “nephrotoxicity”, “renal ischemia – reperfusion injury”, and “Protective.” Results: Present study validates which trimetazidine as a potential agent alleviates kidney dysfunction in experimental models through several mechanisms.Conclusion: Trimetazidine could be considered as promising candidate to treat a variety of kidney diseases in the future.