Browsing by Author "Zahra Jafariazar"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Design and Evaluation of Ocular Controlled Delivery System for Diclofenac Sodium
    (Brieflands, 2015-03-31) Zahra Jafariazar; Nasim Jamalinia; Fatemeh Ghorbani-Bidkorbeh; Seyed Alireza Mortazavi
    Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and redness of patients’ eyes recovering from cataract surgery; however, it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug films were prepared using polymers, namely hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP), Eudragit RL PO, and Eudragit RS PO by solvent casting method considering parameters such as drug: polymer ratio, different polymer combinations as well as plasticizer effect. Ocular films were evaluated for various physicochemical parameters such as physical characters, film thickness, uniformity of weight, drug content, swelling index, mucoadhesion time and in-vitro release study. Ocular films complied with all physicochemical parameters underwent in-vitro release study. Finally, the film formulation with HPMC: Eudragit RS PO 1:1 ratio, Drug: Polymer ratio 1:45 and glycerin as plasticizer showed controlled and prolonged release following the zero order and non-Fickian transport.
  • No Thumbnail Available
    Item
    Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam
    (Brieflands, 2020-07-31) Mahshid Arabi; Seyed Alireza Mortazavi; Zahra Jafariazar; Hassan Farhadnejad; Golnoosh Alipour Harisa; Yousef Fatahi
    In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen formulations were investigated with various concentrations of polymers. The physicochemical characteristics, in-vitro drug release, swelling index, and taste modification of tablets were evaluated. Also, Carr’s index and Hausner ratio were studied. In addition, zero-order, first-order, and Higuchi kinetics were investigated and the results showed that the highest correlation coefficient (R2) is related to zero-order kinetic for formulations B2 and B3. Furthermore, the highest R2 is related to Higuchi kinetic for formulation C3. Formulation B2 showed the maximum release of 99% in 12 h. The results demonstrated that Formulation B2 can be considered as a proper buccal mucoadhesive tablet of meloxicam with desired property.
  • No Thumbnail Available
    Item
    Formulation and In-vitro Characterization of Sustained Release Matrix Type Ocular Timolol Maleate Mini-Tablet
    (Brieflands, 2014-01-31) Seyed Alireza Mortazavi; Zahra Jafariazar; Yasaman Ghadjahani; Hoda Mahmoodi; Farzaneh Mehtarpour
    The purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of glaucoma.