Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle
| Author | zahra Akbari jonoush | en |
| Author | Reza Mansori | en |
| Author | Fatemeh yazdiyan | en |
| Author | Meisam omidi | en |
| Issued Date | 2017-12-31 | en |
| Abstract | Introduction: Nowadays, early cancer detection and effective treatment is crucial for improved prognosis and cancer management and therefore, identification of sensitive and specific methods for early cancer detection is required. One of the methods for early cancer detection is biosensor and gold nanoparticles. The aim of this study was to examine total prostate specific antigen (PSA) biomarker using by nanobio-optical sensor. Materials and Methods: Herein, antibody coated gold nanoparticles was employed in optical immunoassay for detecting of total PSA biomarker. To achieve the goal, antibody was covalently conjugated to gold Nano spheres using 11-Mercaptoundecanoic acid (MUA). Finally, sample serum was investigated by LSPR (localized surface Plasmon resonances) and finally, the results obtained by LSPR and CLIA (Chemiluminescence assay (were compared with each other. Results: The results suggested that nano bio-optical sensor had good potential and good sensitivity in detecting of total PSA. Notably, the proposed nanobio-optical sensor delivered a good sensitivity with average sensitivity 1.1 ng/ml, and a low detection limit of o.9 ng/ml. Conclusion: These results indicate that the nnobio-optical sensor has a great potential in diagnosis of cancer biomarkers. | en |
| DOI | https://doi.org/ | en |
| Keyword | Nanobio-optical Sensor | en |
| Keyword | Prostate specific Antigen | en |
| Keyword | Biomarker | en |
| Keyword | total PSA Monoclonal Antibody | en |
| Keyword | نانوزیست حسگر نوری | en |
| Keyword | بیو مارکر total PSA | en |
| Keyword | آنتیبادی مونوکلونال علیه total PSA | en |
| Publisher | Brieflands | en |
| Title | Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle | en |
| Type | Research Article | en |
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