Construction and evaluation of a model for the prediction of risk factors associated with severe pneumonia in patients with positive hepatitis B core antibody and COVID-19 infection in China
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Date
2024-08-31
0000-0003-3905-5845 Journal Title
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Abstract
Background: Hepatitis B virus (HBV) infection is a high-risk factor for severe COVID-19 cases, and clinicians will strengthen the monitoring of patients with concurrent HBV and COVID-19 infections. However, this is typically focused on patients with active HBV infection. For patients with HBV surface antigen (HBsAg) negative and HBV core antibody (Anti-HBc) positive, they are often considered to have had a past infection that has naturally cleared or to be in a low-replication state, and thus receive less clinical attention. However, in immunosuppressed states, such as during immunosuppressive treatment after COVID-19 infection, the virus in these patients may undergo reactivation. In such cases, it can increase the risk of COVID-19 progressing to a severe illness. So, HBsAg negative and Anti-HBc positive is a potential risk factor for severe COVID-19, the study for Anti-HBc positive combine with COVID-19 infection can help identify high-risk populations. This would allow for the implementation of targeted prevention and management measures, thereby reducing the occurrence of severe COVID-19 cases.