A Review of Cutaneous Squamous Cell Carcinoma Epidemiology, Diagnosis, and Management

Author	Soodeh Kabir	en
Author	Chrysalyne D. Schmults	en
Author	Emily S. Ruiz	en
Issued Date	2018-01-31	en
Abstract	Context: Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and its incidence continues to rise worldwide. While the majority of CSCCs have excellent prognosis, a subset have the propensity to cause poor outcomes. Evidence Acquisition: A thorough Pubmed search was done and a collection of CSCC-relevant articles were selected based on the expert opinion. Results: A number of high-risk factors have been identified including perineural invasion (PNI), desmoplastic growth pattern, poor differentiation, high risk location and large diameter. Various staging systems have been developed based on these high-risk factors. Radiologic imaging is important for high-stage tumors and is likely associated with more aggressive management. Conclusions: Although surgical management is the gold standard, newer therapies such as programmed cell death protein-1 (PD-1) inhibitors show promise for locally advanced or metastatic disease. Despite advances in treatment, early diagnosis and prevention of CSCC is still the most important measure to ensure good outcomes.	en
DOI	https://doi.org/10.5812/ijcm.60846	en
Keyword	Review	en
Keyword	Squamous Cell Carcinoma	en
Keyword	Skin	en
Publisher	Brieflands	en
Title	A Review of Cutaneous Squamous Cell Carcinoma Epidemiology, Diagnosis, and Management	en
Type	Review Article	en

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