Effect of Vitamin B6 Versus Propranolol on Antipsychotic-Induced Akathisia: A pilot Comparative Double-blind Study
| Author | Narges Shams-Alizadeh | en |
| Author | Hamid Bakhshayesh | en |
| Author | Farzin Rezaei | en |
| Author | Ebrahim Ghaderi | en |
| Author | Nasim Shams-Alizadeh | en |
| Author | Kambiz Hassanzadeh | en |
| Issued Date | 2018-03-31 | en |
| Abstract | Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70% of patients. This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced akathisia (AIA). This study was a comparative, double-blind, randomized trial. In the present study, 66 adult patients with antipsychotic-induced akathisia were enrolled and randomized into three groups, and received vitamin B6 300 mg/12 h or 600 mg/12 h or propranolol 20 mg/12 h. The diagnosis of AIA was made by clinical examination and its severity was assessed by the Barnes Akathisia Rating Scale. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2205 | en |
| Keyword | Antipsychotic | en |
| Keyword | Akathisia | en |
| Keyword | Clinical trial | en |
| Keyword | Propranolol | en |
| Keyword | Vitamin B6 | en |
| Publisher | Brieflands | en |
| Title | Effect of Vitamin B6 Versus Propranolol on Antipsychotic-Induced Akathisia: A pilot Comparative Double-blind Study | en |
| Type | Original Article | en |
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