Anxiolytic-Like Effect of Methanol Leaf Extract of <i>Laggera aurita</i> Linn. F. (Asteraceae) in Mice
| Author | Idris Aliyu Guragi | en |
| Author | Hadiza Kyari | en |
| Author | Sani Malami | en |
| Issued Date | 2018-04-30 | en |
| Abstract | Background: Laggera aurita belongs to the Asteraceae family; it is an annual herb found growing as weeds in Sub-Saharan Africa, including Nigeria. In Nigeria, Laggera aurita is used as a remedy for paediatric malaria and in the management of epilepsy. Previous studies on extracts of this plant suggested its anticonvulsant activity via GABA-mediated neurotransmission. Therefore, this study aimed at evaluating anxiolytic-like effect of the plant extract. Methods: Anxiolytic potential of the methanol leaf extract of Laggera aurita was evaluated using staircase, elevated plus maze, hole board, open field, beam walking assay, and diazepam-induced sleep tests. Results: The extract significantly (P < 0.05) decreased the number of rearing in the staircase test at 600 and 300 mg/kg. In the elevated plus maze test, there was a significant (P < 0.05 at 600 and 300 mg/kg) increase in the total number of open arm entries and total time spent in the open arms (600 mg/kg). In the hole board test, the extract significantly (P ≤ 0.05 at 600mg/kg) decreased the number of head dips. Using the open field test, the axiolytic activity of the extract was further reflected by the significant (P < 0.05) decrease in the number of rearing (150, 300, and 600 mg/kg). The effect of the extract on beam walking assay showed a significant (P < 0.05) increase (600 mg/kg) in number of foot slips and time spent on beam. The extract (600 mg/kg) significantly (P < 0.05) increased the duration of sleep induced by diazepam. Conclusions: The results of this study revealed that the leaf extract of Laggera aurita possesses anxiolytic-like properties. | en |
| DOI | https://doi.org/10.5812/archneurosci.63441 | en |
| Keyword | Anxiolytic | en |
| Keyword | Rearing | en |
| Keyword | Diazepam | en |
| Keyword | <i>Laggera aurita</i> | en |
| Publisher | Brieflands | en |
| Title | Anxiolytic-Like Effect of Methanol Leaf Extract of <i>Laggera aurita</i> Linn. F. (Asteraceae) in Mice | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ans-05-02-63441.pdf
- Size:
- 133.36 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF