Hemophagocytic Lymphohistiocytosis-A Rare Complication of Hepatitis A Virus Infection
| Author | Prabhas Prasun Giri | en |
| Author | Priti Khemka | en |
| Author | Swapan Roy | en |
| Author | Sukanta Bhattyacharya | en |
| Issued Date | 2015-07-01 | en |
| Abstract | Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous group of clinical syndromes characterized by activation and subsequent uncontrolled non-malignant proliferation of T-lymphocytes, histiocytes and macrophages leading to a cytokine storm and manifesting as prolonged fever, organomegaly, cytopenia, hyperferritinemia and demonstrable hemophagocytosis in the bone marrow. Case Presentation: Here we present a case of infection associated HLH in a five-year-old girl as a complication of Hepatitis A virus infection. The girl developed acute fulminant hepatic failure with multisystem involvement and was treated with a short course of steroid. Conclusions: Hemophagocytic lymphohistiocytosis is broadly classified as two types, either familial or acquired. The acquired variety may be secondary to any type of infection, mostly viral. Hepatitis A virus is rarely reported to give rise to HLH in the pediatric population. Less intensive immunosuppressive therapy with steroids was successful in maintaining remission. | en |
| DOI | https://doi.org/10.5812/pedinfect.21150 | en |
| Keyword | Hepatitis A | en |
| Keyword | HLH | en |
| Keyword | Hemophagocytosis | en |
| Keyword | steroids | en |
| Publisher | Brieflands | en |
| Title | Hemophagocytic Lymphohistiocytosis-A Rare Complication of Hepatitis A Virus Infection | en |
| Type | Case Report | en |
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