Synthesis of 7-Substituted Fluoroquinolone Derivatives Contain- ing Triazolidine Dione Moiety and In Vitro Evaluation of their Cytotoxic Effects

Abstract

A series of fluoroquinolone derivatives holding triazolidine dione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (SKNMC, MCF7, A2780-CP, SW48, A549, KB, HT-29, HepG2). The cytotoxic activity was assessed using MTT colorimetric assay. Our compounds showed less cytotoxicity than doxorubicin in all studied cell lines. The best results was obtained for the compound 3a on A549 cell line (IC50 = 34.5 μM) and the compound 3b on SW48 (IC50 = 42 μM) and A2780-CP (IC50 = 43 μM) cell lines. The compound 3b that has the phenyl urazole moiety at C-7 position, showed better anticancer effect than the compound 3a on SW48, A2780-CP and MCF7 cell lines.