Vanillic Acid Prevents Interferon-alpha and Cyclosporine A-induced Depressant-like Behavior in Mice
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Date
2022-06-30
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Publisher
Brieflands
Abstract
Background: Interferon-alpha (IFN-α) is a useful therapy for some types of cancers and viral infections. Cyclosporine A (CSA) is an immunosuppressant drug used to reduce the risk of graft rejection. Chronic use of IFN-α and CSA are related to psychological symptoms such as depression. Vanillic acid (VA) is a naturally occurring flavoring substance with antidepressant potential. The aim of this study was to evaluate the effect of VA on depression caused by these two drugs in a mice model.