Naghibione; A Novel Sesquiterpenoid with Antiplasmodial Effect from <i>Dorema hyrcanum </i>Koso-Pol. Root, a Plant Used in Traditional Medicine
| Author | Farzaneh Naghibi | en |
| Author | Saeedeh Ghafari | en |
| Author | Somayeh Esmaeili | en |
| Author | Kristina Jenett-Siems | en |
| Issued Date | 2015-07-31 | en |
| Abstract | Some Dorema species are used in Persian traditional medicine. In the present study the total extract from the roots of Dorema hyrcanum Koso-Pol. was investigated for its in-vitro (pLDH assay) and in-vivo (Peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line MDBK (MTT test). The IC50 values for a chloroquine- sensitive (3D7) and a chloroquine- resistant (K1) strain of Plasmodium falciparum were 28.64 and 9.79 µg/mL, respectively. The inhibition percentage of the rodent parasite, Plasmodium berghei, on day 4 in mice was 77.9% and IC50 value on Madin–Darby bovine kidney cells (MDBK cells) was 59.84 µg/mL. | en |
| DOI | https://doi.org/10.22037/ijpr.2015.1673 | en |
| Keyword | Traditional medicine | en |
| Keyword | <i>Dorema hyrcanum</i> | en |
| Keyword | Antiplasmodial activity | en |
| Keyword | Cytotoxicity | en |
| Keyword | Sesquiterpenoid | en |
| Keyword | Naghibione | en |
| Publisher | Brieflands | en |
| Title | Naghibione; A Novel Sesquiterpenoid with Antiplasmodial Effect from <i>Dorema hyrcanum </i>Koso-Pol. Root, a Plant Used in Traditional Medicine | en |
| Type | Original Article | en |
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