Vitamin D Regulatory Effect on Restraint Stress-Induced Changes in Serum Corticosterone and Hippocampus BDNF Levels in the Male Rats
| Author | Katayoun Sedaghat | en |
| Author | Sara Choobdar | en |
| Author | Ahmad Reza Bandegi | en |
| Author | Zahra Ghods | en |
| Orcid | Katayoun Sedaghat [0000-0001-5424-8640] | en |
| Orcid | Ahmad Reza Bandegi [0000-0003-1834-0583] | en |
| Issued Date | 2021-07-31 | en |
| Abstract | Background: Chronic stress exerts negative effects on cognitive functions through inducing changes in the hippocampus. Brain-derived neurotrophic factor (BDNF) is an essential factor in cognitive functions, which is considerably reduced under chronic stress. 1,25(OH)2 vitamin D plays neuroprotective roles partially by regulating the expression of various neurotrophic factors. Objectives: Since few studies have studied the impact of vitamin D on BDNF levels, we conducted this brief experiment to understand the role of vitamin D in maintaining hippocampal BDNF protein levels by using restraining as a model of chronic stress in rats. Methods: Rats underwent restraint stress 3 h/day for 28 days, during which they received vitamin D (5, 10 μg/kg) or its vehicle (IP, twice weekly). After the stress period, serum corticosterone (CORT) and hippocampus BDNF protein levels were measured. Results: Restraint stress increased serum CORT (P < 0.001) and reduced BDNF protein levels (P < 0.001) as compared to the non-stress group. Vitamin D markedly maintained BDNF levels close to normal (P < 0.001), but did not change CORT levels significantly. Conclusions: This study demonstrated that 3h/day of chronic restraint stress for 28 days boosted serum CORT and declined hippocampal BDNF levels, similar to stronger restraint stress models. Vitamin D maintained BDNF level close to normal in the hippocampus, but it did not affect CORT level significantly. | en |
| DOI | https://doi.org/10.5812/mejrh.115164 | en |
| Keyword | Restraint Stress | en |
| Keyword | Vitamin D | en |
| Keyword | Hippocampus | en |
| Keyword | BDNF | en |
| Keyword | Corticosterone | en |
| Keyword | Rats | en |
| Publisher | Brieflands | en |
| Title | Vitamin D Regulatory Effect on Restraint Stress-Induced Changes in Serum Corticosterone and Hippocampus BDNF Levels in the Male Rats | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- mejrh-8-3-115164.pdf
- Size:
- 667.21 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF