Association Study of the <i>PTPN22 </i>Gene Polymorphisms with Systemic Lupus Erythematosus in Lorestan Province of Iran

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AuthorSeyedeh Zahra Shahrokhien
AuthorSeyed Reza Kazemi Nezhaden
AuthorSharam Baharvand Ahmadien
AuthorMohammad Reza Akhoonden
OrcidSeyed Reza Kazemi Nezhad [0000-0003-2919-1915]en
Issued Date2017-07-31en
AbstractBackground: The protein tyrosine phosphatase non-receptor 22 (PTPN22) gene encodes the lymphoid protein tyrosine phosphatase. Recent studies demonstrated the association between the +1858C > T, -1123G > C variants of PTPN22 gene, and different autoimmune diseases. The current study aimed at examining the association between the polymorphism of PTPN22 gene and systemic lupus erythematosus (SLE) in the Southwest of Iran. Methods: The current study included 120 patients with SLE and 120 healthy volunteers as a control group. Genomic DNA was extracted and the genotyping was performed based on the PCR-restriction fragment length polymorphism (PCR-RFLP) method. Results: Frequency of 1858T allele (P < 0.001, OR = 0.44, 95% CI = 0.291 to 0.663)showed association and frequency of 1123C allele (P = 0.307, OR = 0.811, 95% CI = 0.543 to 1.212)showed no association with SLE in patients compared with the control group in the studied population. Conclusions: Statistical analysis showed no relationship among gender, genotype, and SLE risk. However, there was a significant relationship between age and the SLE risk (P = 0.006).en
DOIhttps://doi.org/10.5812/gct.12023en
KeywordPolymorphismen
KeywordSystemic Lupus Erythematosusen
Keyword<i>PTPN22</i> Geneen
PublisherBrieflandsen
TitleAssociation Study of the <i>PTPN22 </i>Gene Polymorphisms with Systemic Lupus Erythematosus in Lorestan Province of Iranen
TypeResearch Articleen

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