Atypical <i>Klebsiella</i> Species in a Third Level Hospital as Cause of Neonatal Infection
| Author | Damian David Cifuentes Castaneda | en |
| Author | Ninfa Ramirez Duran | en |
| Author | Iliana Espinoza Rivera | en |
| Author | Luz Marcela Caro Gonzalez | en |
| Author | Martin Pablo Antonio Moreno Perez | en |
| Author | Hugo Mendieta Zeron | en |
| Issued Date | 2018-03-31 | en |
| Abstract | Background: The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality. Objectives: To identify atypical Klebsiella species affecting a sample of infected neonates with low antimicrobial response. Methods: Multidrug resistant blood cultures for Klebsiella from a Neonatal Service, were submitted to molecular identification by sequencing analysis of 16S ribosomal RNA. Results: The mean age of the newborns was 14.7 ± 5.6 days. A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole. Conclusions: Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant. | en |
| DOI | https://doi.org/10.5812/jjm.62393 | en |
| Keyword | Amikacin | en |
| Keyword | Neonatal Sepsis | en |
| Keyword | Multidrug Resistance | en |
| Keyword | <i>Klebsiella pneumoniae</i> subsp. <i>ozaenae</i> | en |
| Keyword | <i>K. variicola</i> | en |
| Publisher | Brieflands | en |
| Title | Atypical <i>Klebsiella</i> Species in a Third Level Hospital as Cause of Neonatal Infection | en |
| Type | Brief Report | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- jjm-11-03-62393.pdf
- Size:
- 127.65 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF