Malignant Gastrointestinal Neuroectodermal Tumor: A Case Report and Literature Review
| Author | Mahsa Ahadi | en |
| Author | Shirin Ziafat | en |
| Author | Sara Zahedifard | en |
| Author | Hussein Soleimantabar | en |
| Orcid | Mahsa Ahadi [0000-0003-3741-1543] | en |
| Orcid | Sara Zahedifard [0000-0002-2935-5951] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Introduction: The gastrointestinal neuroectodermal tumor (GNET) is a rare mesenchymal tumor mainly arising in the gastrointestinal tract. Case Presentation: Herein, we describe a case of GNET that had been previously diagnosed as metastatic primitive neuroectodermal tumor (PNET) to the lung and liver and received 30 cycles of adjuvant chemotherapy. The physical exam showed a palpable mass in the lower right quadrant of the abdomen. The tumor mass was composed of diffuse sheets of epithelioid tumor cells, in which osteoclast-like giant cells scattered unevenly. Immunohistochemically, the tumor cells were diffusely positive for SOX10, CD99, and CD56, patchy positive for pan-CK, and negative for desmin, HMB-45, Melan-A, and chromogranin. Conclusions: Consistent with previous studies that reported a secondary GNET following chemotherapy, we assume that the chemotherapy might trigger the tumorigenesis of GNET in this case. | en |
| DOI | https://doi.org/10.5812/ijcm-135231 | en |
| Keyword | Gastrointestinal Neuroectodermal Tumor | en |
| Keyword | SOX10 | en |
| Keyword | Melan-A | en |
| Keyword | HMB-45 | en |
| Publisher | Brieflands | en |
| Title | Malignant Gastrointestinal Neuroectodermal Tumor: A Case Report and Literature Review | en |
| Type | Case Report | en |