Body Roundness Index and Waist-to-Height Ratio are Strongly Associated With Non-Alcoholic Fatty Liver Disease: A Population-Based Study
| Author | Nima Motamed | en |
| Author | Behnam Rabiee | en |
| Author | Gholam Reza Hemasi | en |
| Author | Hossein Ajdarkosh | en |
| Author | Mahmood Reza Khonsari | en |
| Author | Mansooreh Maadi | en |
| Author | Hossein Keyvani | en |
| Author | Farhad Zamani | en |
| Issued Date | 2016-09-01 | en |
| Abstract | Background: A strong association between obesity and non-alcoholic fatty liver disease (NAFLD) has been reported. Objectives: This study was conducted to evaluate if new obesity indices, including a body shape index (ABSI) and body roundness index (BRI), have stronger associations with NAFLD than waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR). Methods: In this cross-sectional study, we utilized the data of 4,872 participants aged 18 - 74 years from a cohort study conducted among 6,143 subjects in northern Iran. Logistic regression analysis was performed on NAFLD as the outcome and obesity measures (based on Z-score values) as potential predictors. Receiver operating characteristic (ROC) analyses were conducted, in which NAFLD was considered as a reference variable and obesity measures as classification variables. The discriminatory ability of the obesity measures was reported based on area-under-the-curves, and the related cut-off points of BRI and WHtR were determined using the Youden index (YI). Results: Based on our results, BRI (OR = 5.484 for men and OR = 3.482 for women) and WHtR (OR = 5.309 for men and OR = 3.854 for women) showed a higher association with NAFLD than ABSI (OR = 1.363 for men and OR = 1.003 for women) and WHR (OR = 3.123 for men and OR = 1.628 for women). The optimal cut-off points for BRI were 4.00 (sensitivity = 82.7%, specificity = 70.8%) for men and 5.00 (sensitivity = 83.3%, specificity = 71.7%) for women. The optimal cut-off points for WHtR were 0.533 (sensitivity = 82.7%, specificity = 70.8%) for men and 0.580 (sensitivity = 83.3%, specificity = 71.7%) for women. Conclusions: While BRI and WHtR have equally strong associations with NAFLD, ABSI and WHR have weaker associations with NAFLD than BRI and WHtR. | en |
| DOI | https://doi.org/10.5812/hepatmon.39575 | en |
| Keyword | Non-Alcoholic Fatty Liver Disease | en |
| Keyword | Obesity | en |
| Keyword | Waist-to-Height Ratio | en |
| Publisher | Brieflands | en |
| Title | Body Roundness Index and Waist-to-Height Ratio are Strongly Associated With Non-Alcoholic Fatty Liver Disease: A Population-Based Study | en |
| Type | Research Article | en |
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