Comparative Study of <i>Berberis vulgaris</i> Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats
| Author | Mohsen Minaiyan | en |
| Author | Alireza Ghannadi | en |
| Author | Parvin Mahzouni | en |
| Author | Elham Jaffari-Shirazi | en |
| Issued Date | 2011-01-31 | en |
| Abstract | Antioxidant and immunomodulatory effects of anthocyanins are abundant in berberry fruits suggesting that they may have beneficial effects on inflammatory bowel diseases (IBD). The present study was carried out to investigate the anti-colitic effect of Berberis vulgaris fruit extract (BFE) compared to berberine chloride (BEC) and corticosteroids using an animal model of acetic acid induced experimental colitis. BFE with three different doses (375, 750, and 1500 mg/Kg) was administered orally or rectally prior to ulcer induction. BEC (10 mg/Kg), prednisolone (5 mg/Kg), hydrocortisone acetate enema (20 mg/Kg) and normal saline (5 mL/Kg) were considered as respective controls. The tissue was assessed macroscopically for damage scores, area, index and weight/length ratio. They were also examined histopathologically for inflammation extent and severity, crypt damage, invasion involvement and total colitis index. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.935 | en |
| Keyword | <i>Berberis vulgaris</i> | en |
| Keyword | Berberine | en |
| Keyword | Barberry fruit extract | en |
| Keyword | Colitis | en |
| Keyword | Rats | en |
| Publisher | Brieflands | en |
| Title | Comparative Study of <i>Berberis vulgaris</i> Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats | en |
| Type | Original Article | en |
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