Evaluation of analgesic and ulcerogenic effect of Methanolic extract of Matricaria Chamomilla L

Abstract

Background: Matricaria chamomilla L has a particular position as analgesic, anxiolitic and carminative in traditional medicine. Objective: To evaluate the analgesic and ulcerogenic effect of methanolic extract of matricaria chamomilla L. Methods: This plant was extracted by suxhlet and percolation methods by methanol 80%. The extract was then concentrated and the weight of direct extract was determined and dissolved in normal salin to produce a different desired concentration. The analgesic effect was evaluated by formalin and hot-plate test in mice and the ulcerogenic effect was studied in rats. Findings: The results indicated that the analgesic effect of percolation extract is higher than the suxhlet extract (P