Journal of Inflammatory Diseases

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The Relationship Between the Full Biophysical Profile and Rapid Biophysical Profile in Antepartum Fetal Surveillance
(Brieflands, 2023-03-31) Hamideh Pakniat; Ezzatalsadat Hajiseid Javadi; Venus Chegini; Nahid Khajevand; Simindokht Molaverdikhani
Background: One of the best tests for the assessment of a fetus is the biophysical profile test which has a significant effect on the fetus’s health and the outcome of pregnancy. The present study was designed to determine the relationship between the full biophysical profile (FBP) and the rapid biophysical profile (RBP) tests in antepartum fetal surveillance. Methods: In this prospective study, Singleton pregnancies (n=209) with more than 34 weeks of gestational age were chosen. Both FBP and RBP tests were performed for all the patients. The main outcome is the Apgar score and neonatal intensive care unit admission analyzed by SPSS software, version 24. The sensitivity, specificity, positive predictive value, and negative predictive value of RBP were calculated. Findings: Out of 209 people who entered the study, 48 women (23.0%) had gestational diabetes, 84 women (40.2%) had hypertension pregnancy (preeclampsia), 45 people (21.5%) had intrauterine growth restriction, and 45 women (21.5%) had post-date pregnancy. For predicting adverse fetal outcomes of pregnancy, the sensitivity, specificity, positive predictive value, and negative predictive value of RBP were 95%, 73%, 52%, and 98%, respectively. Conclusion: According to the statistically significant positive correlation between RBP and FBP and its simple and rapid application, RBP might be an acceptable alternative method for primary antepartum fetal screening tests in overcrowded obstetrics centers.
A comprehensive review of Zika virus infection
(Brieflands, 2018-12-31) Ahmad Tavakoli; Maryam Esghaei; Mohammad Hadi Karbalaie Niya; Arezoo Marjani; Alireza Tabibzadeh; Mohammad Karimzadeh; Seyed Hamid Reza Monavari
Zika virus is a mosquito-borne flavivirus that is becoming a new global threat. Currently, serologic (ELISA) and molecular (RT-PCR) testing make the diagnosis of Zika virus infection. There is no specific drug available for Zika virus infection, and treatment is supportive based on reducing symptoms of disease. Protection against mosquito bites is the most effective way to prevent the infection. In this systematic review, all of the English published papers on Zika virus were assessed before December 2017, and were overviewed. Bibliographic databases had searched including; PubMed, Scopus, Google scholar, and Science Direct by using the keywords such as; “Zika virus”, “Zika fever”, and “Zika infection”. In this review, the pathogenesis, epidemiology, clinical features, transmission, laboratory diagnosis, treatment, and prevention of Zika virus infection were discussed.
Knowledge and practice of medical interns about oral medicine in Hamadan University of Medical Sciences
(Brieflands, 2012-12-31) F Ahmadi Motamayel; H Porhemmat
This was a cross-sectional study to evaluate the degree of awareness and practice of oral medicine by all final-year medical students of Hamadan University of Medical Sciences (69 cases) in 2010. The data was analyzed by chi-square test and T test. According to our findings, the level of knowledge and practice were found to be insufficient in 58 and 55.1% of medical interns, respectively. There was a statistically significant relationship between the level of awareness and practice (P=0.04). Re-evaluation of medical curriculum regarding the oral medicine seems to be necessary for medical students.
Comparison of double phototherapy vs single conventional phototherapy in treatment of Jaundiced neonates
(Brieflands, 2002-06-30) A Zamani; H Shagari; KH Daneshjoo; G SHirvani
Background: Light spectrum, irradiance and surface area of the infant exposed to phototherapy are key elements in determining the efficacy of phototherapy. Objective: To compare the effect of single phototherapy and double phototherapy in treatment of jaundiced neonates. Methods: This experiment was performed on term and preterm neonate in three groups (N=100), on the first ten days of life. The data was collected by the use of a questionnaire, containing information based on sex, gestational age, age in onset of therapy, weight in the onset and end of therapy, duration of phototherapy, range of bilirubin, and its side effects. The data was analyzed and compared by T-test. Findings: The average hours of phototherapy was 48.55 hrs, 45.63 hrs, and 42.83 hrs in the first, second and third group respectively. There was a significant relationship between groups and P value (P=0.0046). There was also a significant relationship between side-effects and kinds of phototherapy (P=0.0425). Conclusion: Phototherapy with four lamp in distance of 20 cm above the neonate is best recommended.
Modification of low dose of neutron induced chromosomal damage by pre and post irradiation of hyperthermia in human blood lymphocytes
(Brieflands, 2002-06-30) D Fatehi
Background: It is believed that a few number of hypoxic cells in the center of tumors may survive after radiotherapy by X and Y-rays. Recently, application of neutron and compound radiation is the center of attention of radiotherapy modalities. Objective: To investigate the effect of hyperthermia on low dose of neutron induced chromosomal damage in human peripheral blood lymphocytes. Methods: Each blood sample was separately exposed to hyperthermia, neutron radiation and radiation accompanying hyperthermia. Different type of damage was investigated after cell culture and chromosome analysis at metaphase stage. Findings: After harvesting and staining, chromosomal aberrations were scored for each specimen. Results indicated that hyperthermia at 41.5°C does not induce chromosomal damage but at 43°C, high frequency of damages were observed (P
nutrition knowledge, attitudes and practices of physicions and medial students
(Brieflands, 2001-12-31) I Nourmohamadi; MH Goharabari
Effect of aerobic exercise on serum leptin response and insulin resistance of patients with type 2 diabetes
(Brieflands, 2013-03-31) M Eizadi; M Karimy; M Kohandel; H Doaly
Background: leptin, a hormone product by adipose tissue, plays an important role in regulation of fat-carbohydrate metabolism. Objective: The objective of this study was to determine the effect of extended aerobic exercise on serum leptin and insulin resistance in male individuals with type 2 diabetes. Methods: This semi-experimental study (2011) was performed on 30 obese adult males with type 2 diabetes who were divided into two control and experimental groups. Blood samples were collected before and after aerobic exercise (3 times/week for 12 weeks) to measure the levels of serum leptin, insulin, and fasting blood sugar in all patients. Fasting glucose and insulin were used for calculating insulin resistance. Data were analyzed using t-test and Pearson’s correlation coefficient. Findings: There was no significant difference between the two groups in all variables at baseline. Serum leptin and fasting glucose levels as well as anthropometrical indexes significantly decreased in experimental group (P
Height Weight of 6 years old pupils in Kashan
(Brieflands, 1998-12-31) A Ershadi
comparision of the attitudes of nurses and relatives of ICU and CCU Patients towards the psychosocial needs of patients relatives
(Brieflands, 2001-12-31) F Abazari; A Abbaszadeh
accuracy of preoperative diagnosis of acute appendicitis in shahid rajaie hospital
(Brieflands, 2001-12-31) S Sadeghipoor Rodsari; M Rohi; H Ansari
Investigating the molars and periodontium health in 7-11 years old children with congenital heart disease in Qazvin
(Brieflands, 2009-12-31) AA Zeinaloo; N Pishva; S Razavi; M Edalat
Background: Children with congenital heart diseases require special dental treatment and care compared to ordinary healthy patients. Therefore, awareness of such specific needs is essential for both the patients and their families. Objective: The aim of the present study was to investigate the health status of molar teeth and periodontium in children with congenital heart diseases and evaluating the awareness of parents about their children’s specific dental care. Methods: A complete dental and oral examination was carried out on 32 children aged 7 to 11 with congenital heart disease followed by assessing the parent's awareness over their children’s specific dental care using a questionnaire. Findings: From 108 permanent molars, 14.8% were with caries and 34.3% with enamel defect. Complete examination of 226 deciduous molars was also indicative of decay and enamel defect in 45.6% and 3.5%, respectively. Of all patients studied, 40.62% were found to have gingivitis and 18.7% with dental abscess. Regarding the parent’s awareness, only 56% of children were revealed to have a previous history of visiting a dentist, and 68.7% of parents were aware of their children’s specific needs for antibiotic prophylaxis. Conclusion: Considering the data obtained in our study, the children were found to have unfavorable dental conditions. Hence, such children require to be visited by a dentist on a regular basis and at the same time provided by necessary information on preventive dental care, treatment and oral hygiene.
Knowledge of general physicians in management of patients with low back pain (2014)
(Brieflands, 2016-11-30) M Abbasi; mahnaz abbasi; mahnaz abbasi
Background: Management of low back pain needs adequate clinical skills, fine utilization of imaging studies and their appropriate explanation, particularly in non-specific low back pains. Therefore, assessment of physicians’ knowledge in this area has a great importance. Objective: The present study was designed to determine knowledge of general physicians in private offices of Qazvin city, Iran in management of patients with acute or chronic low back pain according to the related guideline in clinical skills. Methods: This cross sectional study was conducted in 2014 at the Qazvin University of Medical Sciences, Qazvin city. One hundred fifty general physicians were selected as convenient sampling. The designed questionnaire which assess their knowledge in diagnosis, clinical findings, follow up, and treatment of low back pain was filled by them. The results were analyzed using student t-test and Pierson correlation test. Findings: Sixty physicians were male and 90 were female. Knowledge of physicians about patients’ follow-up has highest score with 65% correct answer. Knowledge about treatment and diagnosis with 46 and 44% correct answer have placed in the next rank, respectively. There was significant association between university of education of physicians with their knowledge of score (P
Effectiveness of multi-component cognitive behavioral intervention on quality of sleep and general health in drug abusers
(Brieflands, 2016-11-30) S Shiri; Sh Banijamali; Gh Sarami Foroshani; H Ahadi
Background: Drug abuse is one of the important problems needs intervention in our country and may influence life and health of a person. One of the important functions and indicates the health of the individual is sleeping. Objective: To determine the effectiveness of multi-component cognitive behavioral intervention on quality of sleep and general health in drug abusers. Methods: This interventional study was conducted in 2015 in drug treatment centers of Qazvin. With consideration inclusion criteria and after preliminary interview, 30 male of treatment center were chosen available from one of the treatment centers of Qazvin and were randomly assigned in two groups. One of the groups received multi-component cognitive behavioral therapy and the control group received no intervention. Research tools were Pittsburg's quality of sleep and general health questionnaires that were filled by clients at baseline and after sessions of the intervention. Data were analyzed by method of analysis of variance differences. Findings: The results demonstrated that multi-component cognitive behavioral therapy significantly improved the quality of sleep and general health in drug abusers in intervention group comparing to control group (P=
Effect of continuous training on the level of PPAR-γ and PRDM16 proteins in adipose tissue in overweight diabetes rats
(Brieflands, 2018-09-30) farhad daryanoosh; Mohsen Salesi; M Shabani
Background: PPAR-γ and PRDM16 proteins have key role in the metabolism of adipose tissue and the conversion of white tissue to brown adipose tissue. But, the role of exercise on these two important proteins has not been studied in subcutaneous adipose tissue. Objective: The aim of this study was to investigate the effect of continuous training on the level of PPAR-γ and PRDM16 proteins in the adipose tissue in overweight male Sprague-Dawley with diabetes. Methods: In this study, 16 two-month old Sprague-Dawley rats with an average weight of 270±20 g were selected and randomly divided into two groups: control (n=8) and continuous training (n=8). The training group exercised according to the training program 4 days a week for 8 weeks while the control group did not have a training program. Independent t-test was used to analyze the data. Findings: There was a significant increase in the expression of PPAR-γ (P=0.004) and PRDM16 (P=0.0001) proteins in the training group compared to control group. Conclusion: Considering the increase of PPAR-γ and PRDM16 proteins in adipose tissue after continuous exercise and the important role of these two proteins in the fat metabolism, aerobic exercise can be an important mechanism for reducing this tissue in obese individuals and converting white tissue to brown.
Serum Anti-heat Shock Protein 27 Antibody Titers in Patients With Dyslipidemia: A Population-based Case-control Study
(Brieflands, 2022-06-30) Fatemeh Sadabadi; Maryam Shahi; Susan Darroudi; Azam Rastgar Moghadam; Sahar Heidari-Bakavoli; Asma Porsa; Sara Saffar Soflaei; Habibollah Esmaily; Mohsen Moohebati; Ghodratollah Salehi Sangani; Gordon A . Ferns; Bibi Razieh Hoseini Farash; Majid Ghayour-Mobarhan
Background: Heat shock protein 27 (HSP27) is found in several cell types of adults, such as cardiomyocytes, and endothelial cells. It is expressed in response to different cellular stress conditions. HSP27 decreases the levels of reactive oxygen species (ROS) and dyslipidemia is closely associated with increased endothelial production of reactive oxygen species (ROS). Objective: Higher serum HSP27 antigen and anti-HSP27 antibodies have been reported in patients with unstable angina and myocardial infarction Methods: This population-based case-control study was conducted in 2018. We investigated serum anti-HSP27 antibody titers in all participants with dyslipidemia from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study (n=8141) and those who were healthy in terms of dyslipidemia (n=1637) using an in-house enzyme-linked immune sorbent assay (ELISA) in individuals with dyslipidemia. Findings: Anti-HSP27 titers were significantly lower in individuals with dyslipidemia compared to people without dyslipidemia (P=0.036). Conclusion: Our results revealed that the anti-HSP27 antibody titer was lower in the participants with dyslipidemia than in the negative group. However, there may be a confounding effect of drug therapy. In a subgroup of dyslipidemic subjects, we observed lower anti-HSP27 antibody titers in patients treated with some drugs (statins or corticosteroids, non-steroidal anti-inflammatory drugs [NSAIDs], or anti-diabetic and anti-hypertensive) compared to subjects untreated with these drugs.
Effect of intermittent normobaric hyperoxia on bloodbrain barrier in a rat model of stroke
(Brieflands, 2013-03-31) M Asheghabadi; MR Bigdeli
Background: Recent studies have shown that the use of prolonged or intermittent normobaric hyperoxia (90 percent) can decrease brain damages caused by stroke. Objective: The aim of this study was to investigate the effects of oxygen radicals in potentiating the blood-brain barrier caused by normobaric hyperoxia in a rat model of stroke. Methods: This was a experimental study performed in spring 2010. A total of 42 male Wistar rats (250-350 g) were initially divided into two main groups. Both group were exposed to normobaric hyperoxia (90 percent HO) and room air (21 percent RA) 4 h/day for 6 days. Later, each main group was subdivided into three subgroups to receive dimethyltiourea. After 24 h, the neurologic deficit scores and blood-brain barrier permeability were assessed. Data were analyzed by one way ANOVA and Mann Whitney U tests. Findings: The medians of neurologic deficit scores and blood-brain barrier permeability decreased in RA and HO (P=0.02). The neurologic deficit score and the reduced brain edema were significantly relived by MT (P=0.43). Conclusion: The blood-brain impermeability caused by intermittent normobaric hyperoxia was relieved by use of oxygen radical scavengers.
Inhibitory effects of Oak fruit Husks hydroalcoholic extract on serum LDL oxidation in vitro
(Brieflands, 2012-03-31) H Ahmadvand; F Abdolahpour; SH Bagheri; M Rashidi Poor; Kh Biranvand; S Chash
Background: Oxidation of low-density lipoprotein (LDL) has been strongly implicated in the pathogenesis of atherosclerosis. The use of some antioxidant compounds in dietary food stuff such as vitamin E and Oak fruit (Quercus) husks hydroalcoholic extract (OHE) may inhibit the production of oxidized LDL and decrease both the development and the progression of atherosclerosis. Objective: The present work investigated the effects of OHE on LDL oxidation induced-CuSO4 quantitatively in vitro. Methods: This study was an experimental research performed in Khoramabad province during 2010. Fasting blood samples were collected from normal people followed by LDL isolation. The population study was divided into five groups (1: control 2: those exposed to CuSO4 without treatment, and groups 3-5: those exposed to CuSO4 and treated with OHE (0.2, 2, and 20 µg/ml, respectively). Later, the formation of conjugated dienes, lag time, and malondialdehyde (MDA) were measured. Inhibition of Cu-induced oxidation was investigated in the presence of several concentrations of OHE (0.2, 2 and 20 µg/ml). Data were statistically analyzed by SPSS 13 using Mann Whitney test. Findings: OHE was found to have the ability to inhibit the CuSO4-induced LDL oxidation. Administration of oak (Quercus) husks hydroalcoholic extract (OHE) showed an increased rate of 2.2, 3, and 4.3 fold s at concentrations ranging from 0.2 to 20µg/ml against oxidation in vitro. Also conjugated dienes decreased 13.33%, 46.66% and 80.00% at concentrations ranging from 0.2 to 20 µg/ml of OHE, respectively. The inhibitory effects of OHE on LDL oxidation at concentrations used were dose-dependent. Conclusion: This study showed that the OHE has the potential to prevent the oxidation of LDL in vitro and it may suggest that this compound is capable of producing a similar effect in vivo.
Contraceptive methods and attitude of women seeking termination of unwanted pregnancies toward subsequent childbirth
(Brieflands, 2000-06-30) M Hassanabadi; S. Kaheni; HR. Kamiyare; AR. Saadtjoo
Abstract Background: An increasing proportion of unwanted pregnancies are due to contraceptive failure. Objective: To determine contraceptive methods and attitude toward subsequent childbirth among women requesting termination or prevention of unwanted pregnancy. Methods: Through a consective sampling method, a descriptive study was conducted on 138 women attending health services in Birjand , and seeking termination of an unwanted pregnancy .The cases were interviewed by the use of a questionnaire.Analysis included frequencies and descriptive presentation of major variables. Findings: The two most common birth control methods were condom and coitus interruptus(88.4 and 10.2 respectively ). 50.7% had negative attitude toward subsequent childbirth. 1.4% did not use any contraceptive method, and 47.9% had positive attitude toward subsequent childbirth, but sought termination of unwanted pregnancy to lengthen the time between births. Conclusion: Couples who wish to lengthen the time between births but use high risk contraceptive methods such as condom or coitus interrupts might face unwanted pregnancies.
Effect of education on midwives' knowledge, attitude and practice about non-pharmacologic labor pain relieving methods
(Brieflands, 2011-09-30) M Geranmayeh; T Hadian; A Rezaepur; E Akhondzadeh; H Haghani
Background: Management of labor pain is one of the main goals of maternity care. Non-pharmacologic approaches toward this goal are consistent with midwifery care and the method of choice for many women. Midwives have a pivotal role in using different pain relief approaches. Objective: This study was designed to evaluate the role of education on midwives' knowledge, attitude, and practice towards pain reducing approaches during labor. Methods: This was a quasi-experimental study carried out at labor wards within the hospitals affiliated to Gilan University of Medical Sciences, Iran. Data were collected using a questionnaire confirmed by a panel of experts and test-retest method for its validity and reliability, respectively. A total of 59 midwives were chosen by quota sampling and participated in a one-day workshop. Pretest and post-test questionnaire were completed before and four months after education. Data were analyzed by descriptive and inference statistical methods using SPSS. Findings: Results showed that the midwives' knowledge, attitude and practice about pain relieving methods changed significantly following workshop (p
Molecular detection of Chlamydia Trachomatis and Mycoplasma Hominis in endometriosis lesions
(Brieflands, 2016-12-31) F Azizvakili; Geita Saadatnia; P Salehian; Nahid Bakhtiari; S Rezaei
Background: Retrograde of menstrual blood into the peritoneal cavity is one of the accepted theories for initiation of endometriosis although indicated that other factors are involved in pathogenesis. Investigation of infectious agents is important in this regard. Objective: To investigate the presence of bacterial infections; Chlamydia trachomatis and Mycoplasma Hominis as risk factors in endometriosis lesions. Methods: This case-control study was conducted in Sarem Hospital in 2014. DNA was extracted from 90 paraffin-embedded blocks included 40 endometriosis tissue samples, 23 samples of endometrial tissue from the same patients and 27 samples of endometrial tissue of the patients without endometriosis, and molecular analysis were performed using polymerase chain reaction. Results were analyzed by Fisher Exact Test and McNemar Test. Findings: Chlamydia trachomatis infection was seen in 11 (27.5%) endometriosis tissue, 3 (13%) normal tissue from patients and 10 (37%) in patient without endometriosis. Mycoplasma hominis was diagnosed in 11 (27.5%) endometriosis tissue, 7 (30.4%) of normal tissue from patients and one patient without endometriosis (3.7%). These differences show significant relations between infection with Mycoplasma hominis and endometriosis. Conclusion: The findings of this study did not show significant association between Chlamydia trachomatis infections and endometriosis. However; it seems Mycoplasma hominis infection can increase the risk of endometriosis incidence.

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