Determination of Rifampin and Isoniazid resistant mycobacterium tuberculosis in Kermanshah (2006-2008)

Abstract

Tuberculosis is one of the most important infectious diseases and a major cause of morbidity and mortality in developing countries. Multi drug resistant tuberculosis is a new threat, which can result in a high case fatality rate. This study was conducted to define the incidence of multidrug resistant tuberculosis in Kermanshah. ­Antibiogram was performed on­­ PCR-confirmed isolates of mycobacterium tuberculosis by using the proportion method. Eight cases (57.1%) showed resistance to ­1µg/ml Isoniazid­. Resistance to Rifampicin was identified in 46.2% ­of cases.­ This study showed a high rate of single drug and multidrug resistance. We recommend antibiogram for all cases of tuberculosis.