Brain Serotonin 5-HT2α Receptor Density in Male Rats Can Be Affected by Bisphenol A and Passive Avoidance Learning
| Author | Mahnaz Taherianfard | en |
| Author | Soodeh Rowhanirad | en |
| Author | Seyed Ali Arefkashfi | en |
| Orcid | Mahnaz Taherianfard [0000-0002-8819-1619] | en |
| Orcid | Soodeh Rowhanirad [0000-0002-8139-6144] | en |
| Orcid | Seyed Ali Arefkashfi [0009-0000-7427-0650] | en |
| Issued Date | 2026-06-30 | en |
| Abstract | Background: Bisphenol A (BPA) may adversely affect the nervous system. Objectives: This study aimed to assess the effects of passive avoidance learning on BPA-induced toxicity, as indicated by serotonin 5-HT2α receptor density in the cerebellum, basolateral amygdala, and hippocampus of male rats. Methods: Thirty male rats (200 - 220 g) were allocated to six experimental groups. BPA was administered orally for 15 consecutive days. Learning and memory performance were assessed using a passive avoidance shuttle-box paradigm. Serotonin 5-HT2α receptor density was evaluated by immunohistochemistry in the selected brain regions. Immunohistochemical labeling was quantified by measuring color parameters using image-analysis software. Results: BPA at both doses reduced 5-HT2α serotonin receptor density in the examined brain structures. Passive avoidance learning mitigated the toxic effects of BPA on 5-HT2α receptor density in these structures. Conclusions: Overall, BPA exposure downregulated 5-HT2α receptors in the hippocampus, amygdala, and cerebellum of male rats, whereas passive avoidance learning and memory were associated with an increased receptor density. | en |
| DOI | https://doi.org/10.5812/jkums-173063 | en |
| URI | https://brieflands.com/journals/jkums/articles/173063 | en |
| Keyword | Bisphenol A | en |
| Keyword | Passive Avoidance Learning | en |
| Keyword | Immunohistochemistry | en |
| Keyword | 5-HT2α Subunit of the Serotonin Receptor | en |
| Keyword | Male Rats | en |
| Publisher | Brieflands | en |
| Title | Brain Serotonin 5-HT2α Receptor Density in Male Rats Can Be Affected by Bisphenol A and Passive Avoidance Learning | en |
| Type | Research Article | en |