Mycophenolic Acid Concentration on Vietnamese Renal Transplant Recipients
| Author | Dung Thi Mai Do | en |
| Author | An Phan Hai Ha | en |
| Author | Dong Van Le | en |
| Author | Lan Thi Phuong Dam | en |
| Author | Thuan Quang Huynh | en |
| Orcid | Dung Thi Mai Do [0000-0002-2736-8361] | en |
| Orcid | An Phan Hai Ha [0000-0002-9734-8956] | en |
| Orcid | Dong Van Le [0000-0003-2081-6931] | en |
| Orcid | Lan Thi Phuong Dam [0000-0002-9747-1612] | en |
| Orcid | Thuan Quang Huynh [0000-0002-0162-171X] | en |
| Issued Date | 2021-01-23 | en |
| Abstract | Background: Kidney recipients often use a calcineurin inhibitor and a proliferation inhibitor after transplantation. The therapeutic drug monitoring for calcineurin inhibitor is more simple and feasible in clinical than proliferation inhibitor. In Vietnam, mycophenolic acid is a popular proliferation inhibitor used for transplantation patients. Although therapeutic mycophenolic acid monitoring is so important in treating kidney transplantation, the monitoring is still difficult to execute in Vietnam. Objectives: This study aimed to determine the MPA concentration on Vietnamese renal transplant recipients. Methods: This observational study was conducted on 35 adult kidney recipients to evaluate the MPA concentration at five sampling time points (predose, 1, 2, 3, and 6 hours) on day 3, day 10, and month 6 after transplantation. Results: Plasma MPA trough levels (C0) were 2.32 ± 1.47;1.58 ± 1.39; 2.29 ± 1.4 mg/L and the MPA-AUC0-12 h values were 50.1 ± 20.4; 41.9 ± 14.5; 60.3 ± 25.9 mg.h/L on day 3, day 10, and month 6. The number of patients who reached MPA-AUC0-12 h values of 30 - 60 mg.h/L was 18 (51.4%), 23 (65.7%) and 17 (51.5%) on day 3, day 10, and month 6, respectively. The number of patients who achieved the MPA C0 values of 1.5 - 2.5 mg/L was 15 (42.9 %), 14 (40%), and 10 (30.3%) on day 3, day 10, and month 6, respectively; and the linear correlation coefficients between AUC0-12 h and C0 were 0.652, 0.415, and 0.752, respectively. Conclusions: In renal transplant patients, the MPA-AUC0-12 h was lower on day 3 and day 10 post-transplantation than month 6 for the half dose of MMF or MPS. Therefore, MPA therapeutic drug level should be monitored usually in transplantation patients who use MPA. | en |
| DOI | https://doi.org/10.5812/numonthly.108768 | en |
| Keyword | Myfortic | en |
| Keyword | Cellcept | en |
| Keyword | Mycophenolic Acid | en |
| Keyword | Renal Transplantation | en |
| Publisher | Brieflands | en |
| Title | Mycophenolic Acid Concentration on Vietnamese Renal Transplant Recipients | en |
| Type | Research Article | en |
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