Role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Cytologically Indeterminate Thyroid Nodules
| Author | Gulgun Buyukdereli | en |
| Author | Yasemin Aktar | en |
| Author | Ertan Kara | en |
| Author | Aysun Uguz | en |
| Author | Husnu Sonmez | en |
| Issued Date | 2016-01-01 | en |
| Abstract | Background: Thyroid nodules with indeterminate fine-needle aspiration biopsy (FNAB) results remain a diagnostic dilemma, because 70 - 85% of these nodules have been found to be benign after thyroid surgery. Objectives: The purpose of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative diagnosis of cytologically indeterminate nodules. Patients and Methods: Forty-six patients were included in this study. These individuals had undergone FDG PET/CTs for the preoperative evaluation of thyroid nodules with indeterminate FNAB results. The results of the preoperative PET/CT scans were compared with the postoperative pathological results and statistically analyzed. Results: Of the 46 patients included in our study, the histopathology of the surgical specimens revealed thyroid cancer in 17 individuals (37%, 17/46). The PET/CT scan showed a positive result in 27 patients. Of these, 16 patients (59.3%) were found to have thyroid carcinomas. In addition, the PET/CT scan was considered to be negative in 19 patients, 18 (94.7%) of whom had benign lesions. For the detection of malignant lesions, the values for the sensitivity and specificity, and the positive predictive and negative predictive values were 94%, 62%, 59%, and 95%, respectively. Conclusion: The FDG PET/CT showed a high sensitivity and a high negative predictive value for identifying malignancies in thyroid nodules with indeterminate FNAB results. Therefore, the FDG PET/CT may be a helpful tool in the clinical management of these nodules. When an FDG positive lesion is detected, further examination is recommended. | en |
| DOI | https://doi.org/10.5812/iranjradiol.21186 | en |
| Keyword | Thyroid Nodules | en |
| Keyword | FDG PET/CT | en |
| Keyword | Indeterminate | en |
| Keyword | Fine Needle Aspiration Biopsy | en |
| Publisher | Brieflands | en |
| Title | Role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Cytologically Indeterminate Thyroid Nodules | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 56231-pdf.pdf
- Size:
- 627.23 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF