Identification of Viral Causes in Cerebrospinal Fluid of Patients Under Investigation for Central Nervous System Infections During the COVID-19 Epidemic: A Cross-Sectional Study
| Author | Nasrin Aliabadi | en |
| Author | Nahid Heydari Marandi | en |
| Author | Gholamreza Pouladfar | en |
| Author | Seyedeh Sedigheh Hamzavi | en |
| Author | Marzieh Hosseini | en |
| Author | Rosemina Bahrololoom | en |
| Author | Marzieh Jamalidoust | en |
| Author | Mazyar Ziyaeyan | en |
| Orcid | Nasrin Aliabadi [0000-0002-2202-4148] | en |
| Orcid | Nahid Heydari Marandi [0000-0002-1682-0244] | en |
| Orcid | Gholamreza Pouladfar [0000-0001-8676-4607] | en |
| Orcid | Seyedeh Sedigheh Hamzavi [0000-0002-7081-0127] | en |
| Orcid | Marzieh Hosseini [0009-0007-5519-0525] | en |
| Orcid | Marzieh Jamalidoust [0000-0002-7034-1236] | en |
| Orcid | Mazyar Ziyaeyan [0000-0001-9371-7518] | en |
| Issued Date | 2025-04-30 | en |
| Abstract | Background: Although viral etiology of central nervous system (CNS) infections such as meningitis and encephalitis are investigated widely worldwide, it remains to be declared under the COVID-19 pandemic. Objectives: The focus of this study was to examine the etiology of viral CNS infections in patients hospitalized in a single referral hospital during the outbreak in Iran. Methods: We retrospectively collected the cerebrospinal fluid (CSF) samples and reviewed the medical records of patients hospitalized with suspected viral CNS infection in Shiraz, a large city in southern Iran, from April 2021 to May 2022. One hundred sixty-six CSF samples were tested primarily for detection of HSV-1 and -2 and retrospectively analyzed by primers polymerase chain reaction (PCR) targeted to coronavirus 2 (SARS-CoV-2), human herpesviruses1 to 6 (HHV-1 to 6), polyomaviruses JC, and enteroviruses (EV). Results: Of the total CSF samples analyzed by PCR, 22 (13.3%) were positive for only one viral pathogen, and just one (0.6%) sample was detected with multiple viruses (HSV-1 and CMV). The SARS-CoV-2 (6 cases) was the second most common viral etiology just after Herpes simplex virus-1 (HSV-1) 6.6% (11 cases). Other detected viruses were CMV for 1.8% (3 cases), VZV for 1.2% (2 cases), and JC for 0.6% (1 case) of the cases. Conclusions: This study highlights the prevalence of viral pathogens in CSF samples from patients with suspected meningitis at Namazi Teaching Hospital. Notably, HSV-1 was the most common virus detected, followed by SARS-CoV-2. These findings underscore the importance of viral testing in the diagnosis and management of meningitis. | en |
| DOI | https://doi.org/10.5812/apid-147939 | en |
| Keyword | Central Nervous System | en |
| Keyword | Cerebrospinal Fluid | en |
| Keyword | Cytomegalovirus Infections | en |
| Keyword | Epstein-Barr Virus Infections | en |
| Keyword | Herpes Simplex Infections | en |
| Keyword | SARS-CoV-2 | en |
| Keyword | Varicella-Zoster Virus Infections | en |
| Publisher | Brieflands | en |
| Title | Identification of Viral Causes in Cerebrospinal Fluid of Patients Under Investigation for Central Nervous System Infections During the COVID-19 Epidemic: A Cross-Sectional Study | en |
| Type | Research Article | en |
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