Interactive Effect of Grape Seed Nanoparticle Extract and Resistance Training on Antioxidant System Function in Myocardial Infarction Rat Model
| Author | Ebrahim Khaki | en |
| Author | Khosro Jalali Dehkodi | en |
| Author | Farzaneh Taghian | en |
| Author | Seyed Ali Hosseini | en |
| Orcid | Ebrahim Khaki [0000-0002-5146-496X] | en |
| Orcid | Khosro Jalali Dehkodi [0000-0003-0210-5984] | en |
| Orcid | Farzaneh Taghian [0000-0001-9531-2952] | en |
| Orcid | Seyed Ali Hosseini [0000-0001-9122-3952] | en |
| Issued Date | 2023-01-31 | en |
| Abstract | Background: The use of herbal supplements and exercise to treat chronic diseases and metabolic disorders is a common practice. Objectives: This study aimed to investigate the effect of eight weeks of grape seed nanoparticle extract and resistance training on SOD, MDA, and NRF-1 expression in the myocardial infarction rat model. Methods: In this experimental trial, 25 Wistar rats were randomly divided into five groups: (1) control, (2) MI, (3) RT + MI, (4) GS + MI, and (5) RT + MI + GS. Resistance training was performed for eight weeks and five sessions per week. Also, 150 mg of grape seed extract was gavage daily. One-way analysis of variance and the Tukey test was used to compare groups at the P ≤ 0.05. Results: Resistance training with grape seed significantly increased NRF-1 gene expression (P = 0.001) and SOD (P = 0.01) compared to MI grope. While resistance training with grape seed significantly reduced MDA compared to the MI group (P = 0.01). Conclusions: It seems that resistance training with grape seed consumption has a more positive effect on increasing NRF-1 gene expression and improving the antioxidant system in the heart tissues of rats with myocardial infarction rather than using each alone. | en |
| DOI | https://doi.org/10.5812/gct-123703 | en |
| Keyword | Resistance Training | en |
| Keyword | Grape Seed | en |
| Keyword | <i>NRF-1</i> | en |
| Keyword | <i>MDA</i> | en |
| Keyword | <i>SOD</i> | en |
| Keyword | Myocardial Infarction | en |
| Publisher | Brieflands | en |
| Title | Interactive Effect of Grape Seed Nanoparticle Extract and Resistance Training on Antioxidant System Function in Myocardial Infarction Rat Model | en |
| Type | Research Article | en |
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