Portal Hypertension as Immune Mediate Disease
| Author | Sara Manti | en |
| Author | Lucia Marseglia | en |
| Author | Gabriella D Angelo | en |
| Author | Martina Filippelli | en |
| Author | Caterina Cuppari | en |
| Author | Eloisa Gitto | en |
| Author | Claudio Romano | en |
| Author | Teresa Arrigo | en |
| Author | Carmelo Salpietro | en |
| Issued Date | 2014-06-01 | en |
| Abstract | Context: Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promoting hepatic architectural distortion. Evidence Acquisition: A literature search of electronic databases was undertaken for the major studies published from 1981 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the keywords: "portal hypertension, children, immune system, endocrine system, liver fibrosis". Results: It is believed that PH results from three “phenotype”: ischemia-reperfusion, involving nervous system (NS); edema and oxidative damage, involving immune system; inflammation and angiogenesis, involving endocrine system. However, its exact cause still underdiagnosed and unknown. Conclusions: PH is a dynamic and potentially reversible process. Researchers have tried to demonstrate mechanisms underlying PH and its related-complications. This review focuses on the current knowledge regarding the pathogenesis, and immune, endocrine-metabolic factors of disease. The strong positive association between immune system and development of PH could be efficient to identify non-invasive markers of disease, to modify prognosis of PH, and to development and application of specific and individual anti-inflammatory therapy. | en |
| DOI | https://doi.org/10.5812/hepatmon.18625 | en |
| Keyword | Portal Hypertension | en |
| Keyword | Children | en |
| Keyword | Immune System | en |
| Keyword | Endocrine System | en |
| Keyword | Liver Fibrosis | en |
| Publisher | Brieflands | en |
| Title | Portal Hypertension as Immune Mediate Disease | en |
| Type | Review Article | en |
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