Hepatitis B Virus DNA is Absent in Lebanese Blood Donors Who Are Positive for Both Anti-Hbc and Anti-Hbs Antibodies
| Author | Ghada Kchour | en |
| Author | Mohammad Fayyad-Kazan | en |
| Author | Antoine Haddad | en |
| Author | Bassam Badran | en |
| Author | Mahdi Tarhini | en |
| Issued Date | 2017-02-28 | en |
| Abstract | Background: A major risk during blood transfusion is the transmission of infectious agents such as Hepatitis B virus (HBV). Screening for anti-HBc antibodies has long been used to test HBV infection and thus, blood safety. However, the development of advanced tools enabling HBV-DNA detection rendered the diagnostic benefit of anti-HBc test uncertain. Objectives: In this study, we aimed to evaluate the relationship between HBV-DNA, anti-HBs, and anti-HBc loads. Methods: Sera of 7200 blood donors were first screened for HBs antigen (HBsAg) and anti-HBc antibody. Samples that were found to be HBsAg-negative but anti-HBc-positive were further tested for anti-HBs and HBV-DNA. Results: Of the 7200 tested samples, 7143 (99.2%) were HBsAg-negative, while the remaining 57 (0.8%) samples were HBsAg-positive. Among the HBsAg-negative samples, 490 (6.8%) were anti-HBc-positive. Of the anti-HBc positive samples, 397 (81%) were anti-HBs-positive, while the remaining 93 (19%) samples were anti-HBs-negative. Interestingly, all of the anti-HBc positive samples, which also were positive for anti-HBs, exhibited negative HBV-DNA results. On the other hand, the anti-HBc positive samples, which were negative for anti-HBs, showed both negative and positive HBV-DNA results. Conclusions: Blood samples which are positive for both anti-HBc and anti-HBs are characterized by negative HBV load. | en |
| DOI | https://doi.org/10.5812/hepatmon.44787 | en |
| Keyword | Hepatitis B Virus (HBV) | en |
| Keyword | Anti-HBc | en |
| Keyword | Anti-HBs | en |
| Keyword | Blood Safety | en |
| Publisher | Brieflands | en |
| Title | Hepatitis B Virus DNA is Absent in Lebanese Blood Donors Who Are Positive for Both Anti-Hbc and Anti-Hbs Antibodies | en |
| Type | Research Article | en |
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