In Silico Design and Analysis of TGFαL3-SEB Fusion Protein as “a New Antitumor Agent” Candidate by Ligand-Targeted Superantigens Technique
| Author | Abbas Ali Imani-Fooladi | en |
| Author | Forough Yousefi | en |
| Author | Seyed Fazloallah Mousavi | en |
| Author | Jafar Amani | en |
| Issued Date | 2014-09-30 | en |
| Abstract | Background: Bacterial superantigen Staphylococcal Enterotoxins (SEs), has stimulated polyclonal T cells irrespective of their antigen specificity, resulted a massive release of cytokines, and suggested that they could be assigned as a candidate of new antitumor agents. Recent attempts have done to specifically target superantigens towards tumors, subsequently Monoclonal antibodies and tumor-related ligands have employed as targeting molecules of superantigen for the preclinical treatment of different tumors. Here, we have evaluated TGFαL3- SEB fusion protein as a new antitumor candidate by genetically fusing the third loop of transforming growth factor alpha (TGFαL3) to Staphylococcal Enterotoxin type B. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/ijcm/articles/80546 | en |
| Keyword | Enterotoxin type B | en |
| Keyword | Growth Factor α | en |
| Keyword | Cancer Immunotherapy | en |
| Keyword | in silico modeling | en |
| Publisher | Brieflands | en |
| Title | In Silico Design and Analysis of TGFαL3-SEB Fusion Protein as “a New Antitumor Agent” Candidate by Ligand-Targeted Superantigens Technique | en |
| Type | Research Article | en |
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