Progressive Multifocal Leukoencephalopathy as the First Manifestation of AIDS: A Rare Case Report
| Author | Atousa Hakamifard | en |
| Author | Azin Shayganfar | en |
| Author | Farzin Khorvash | en |
| Author | Vahid Shaygannejad | en |
| Author | Katayoon Tayeri | en |
| Author | Ali Talebi Khorzoughi | en |
| Orcid | Atousa Hakamifard [0000-0001-9456-2239] | en |
| Orcid | Farzin Khorvash [0000-0003-2542-9885] | en |
| Issued Date | 2020-02-29 | en |
| Abstract | Introduction: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by the JC virus (JCV). Case Presentation: A 47-year-old woman with no history of any underlying diseases was hospitalized at our center with a loss of consciousness and aphasia. The investigation of the patient’s history revealed that she had been hospitalized in another hospital a month earlier due to right hemiparesis and dysarthria. Brain imaging was repeated that revealed demyelinating lesions. The laboratory studies showed a positive human immunodeficiency virus (HIV) serology. The polymerase chain reaction (PCR) of the cerebrospinal fluid (CSF) for JCV turned out positive and the diagnosis of PML was established. Conclusions: Progressive multifocal leukoencephalopathy should always be considered as an important differential diagnosis in patients with demyelinating brain lesions and HIV testing should be considered in these patients, as well. | en |
| DOI | https://doi.org/10.5812/archcid.85447 | en |
| Keyword | Progressive Multifocal Leukoencephalopathy | en |
| Keyword | PML | en |
| Keyword | Human Immunodeficiency Virus | en |
| Keyword | JCV | en |
| Keyword | Acquired Immunodeficiency Syndrome | en |
| Keyword | AIDS | en |
| Keyword | Case Report | en |
| Publisher | Brieflands | en |
| Title | Progressive Multifocal Leukoencephalopathy as the First Manifestation of AIDS: A Rare Case Report | en |
| Type | Case Report | en |