Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions
| Author | Effat Souri | en |
| Author | Ali Hatami | en |
| Author | Nazanin Shabani Ravari | en |
| Author | Farhad Alvandifar | en |
| Author | Maliheh Barazandeh Tehrani | en |
| Issued Date | 2013-04-30 | en |
| Abstract | A stability indicating High-Performance Liquid Chromatography (HPLC) method was validated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidative conditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mM KH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method was linear over the range of 1-20 μg/mL of cetirizine dihydrochloride (r2 > 0.999) and the within-day and between-day precision values were less than 1.5%. The results showed that cetirizine dihydrochloride was unstable in 2 M HCl and 0.5% H2O2. The kinetics of the acidic degradation showed a pseudo-first-order reaction in the temperature range of 70-90°C. In addition, the kinetics of hydrogen peroxide mediated degradation was pseudo-first-order in the temperature range of 50-80°C. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1312 | en |
| Keyword | Cetirizine | en |
| Keyword | High-Performance Liquid Chromatography (HPLC) | en |
| Keyword | Degradation | en |
| Keyword | Kinetics | en |
| Keyword | Stability | en |
| Publisher | Brieflands | en |
| Title | Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-12-287.pdf
- Size:
- 557.01 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF