Successful Treatment of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Meningitis with Combination Therapy of Meropenem and Amikacin
| Author | Eman Hamza | en |
| Author | Shahinda Rezk | en |
| Author | Hassan Eshra | en |
| Author | Heba Selim | en |
| Author | Mohamed Samir Turkey | en |
| Orcid | Mohamed Samir Turkey [0000-0002-1576-0841] | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Introduction: The widespread use of carbapenems increased the prevalence of carbapenem-resistant Enterobacteriaceae with subsequent increases in mortality due to extremely limited treatment options. Following neurosurgical procedures, carbapenem-resistant Klebsiella pneumoniae (CRKP) is the main cause of central nervous system (CNS) infections. The optimal antimicrobial treatment of such infections has not yet been defined. Case Presentation: We present a 4-month-old boy with an extra-ventricular drain-related CNS infection with CRKP. Although meropenem minimum inhibitory concentration (MIC) for the bacterial isolate was ≥ 16 mg/L and it harbored blaNDM, blaVIM, and blaOXA-48-like carbapenemase genes, this infection was effectively treated with a combination therapy of intravenous (IV) double dose extended infusion of meropenem in addition to amikacin. Conclusions: This successful treatment regimen for CRKP-causing meningitis may pave the way to manage severe CNS infections with extensive-drug-resistant bacteria in infants and children without inserting an external drain or intra-thecal antibiotic administration. | en |
| DOI | https://doi.org/10.5812/apid-140658 | en |
| Keyword | Carbapenem-Resistant <i>Klebsiella</i> | en |
| Keyword | Intravenous | en |
| Keyword | Extended Infusion | en |
| Keyword | Meropenem | en |
| Keyword | Amikacin | en |
| Publisher | Brieflands | en |
| Title | Successful Treatment of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Meningitis with Combination Therapy of Meropenem and Amikacin | en |
| Type | Case Report | en |
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