The Role of Cyclooxygenase-2 in Signaling Pathways Promoting Colorectal Cancer
| Author | Abasalt Hosseinzadeh Colagar | en |
| Author | Abdolvahab Moshtaghian | en |
| Author | Tahereh Zahedi | en |
| Issued Date | 2023-02-28 | en |
| Abstract | Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been observed in chronic inflammatory diseases and various cancers. COX-2 promotes colorectal cancer through various signaling pathways. COX-2 plays its role in colorectal cancer by induction of Bcl-2 expression, and β-catenin pathway activation, and leads to translocate of the NF-κB from the cytoplasm to the nucleus. NF-κB transcription factor plays an important role in physiological processes such as cell proliferation, cell death, and inflammation. Deregulation of NF-κB and its impact on the signaling pathway play a critical role in the development and progression of colorectal cancer. Another factor that plays a role in the development and progression of colorectal cancer is the β-catenin gene. Mutations in the β-catenin gene have been found in more than half of colorectal cancer patients. Bcl-2 is also known as an anti-apoptotic factor in all types of cancers. COX-2 controls all these pathways. Therefore, targeting COX-2 can be proposed as a therapeutic strategy for the treatment of colorectal cancer. The purpose of this review is to investigate the signaling pathways related to COX-2 in colorectal cancer | en |
| DOI | https://doi.org/ | en |
| Keyword | Cyclooxygenase-2 | en |
| Keyword | Prostaglandin E2 | en |
| Keyword | Colorectal ژancer | en |
| Keyword | NF-κB | en |
| Keyword | Bcl-2 | en |
| Keyword | β-catenin | en |
| Keyword | سیکلواکسیژناز-2 | en |
| Keyword | پروستاگلاندین E2 | en |
| Keyword | سرطان کولورکتال | en |
| Keyword | β -کاتنین | en |
| Publisher | Brieflands | en |
| Title | The Role of Cyclooxygenase-2 in Signaling Pathways Promoting Colorectal Cancer | en |
| Type | Research Article | en |
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