Lower Intrafamilial Transmission Rate of Hepatitis B in Patients With Hepatitis D Coinfection: A Data-Mining Approach
| Author | Omid Pournik | en |
| Author | Seyed Moayed Alavian | en |
| Author | Leila Ghalichi | en |
| Author | Bashir Hajibeigi | en |
| Author | Amir Reza Razavi | en |
| Author | Saeid Eslami | en |
| Orcid | Seyed Moayed Alavian [0000-0002-4443-6602] | en |
| Issued Date | 2013-05-01 | en |
| Abstract | Background: The presence of an infected family member significantly increases the risk of HBV transmission, but many socio-demographic and viral characteristics of family members affect the transmission rate. Objectives: In this study, we have used data mining techniques to investigate the impact of different variables in intrafamilial transmission of HBV infection. Patients and Methods: demographic information, viral markers, and medical history of 330 patients with chronic hepatitis B and their offspring attending a referral center in Tehran were collected. Data-mining techniques were administered to detect patterns. Results: The overall transmission rate was 15.7% (5.4% and 27.3% for male and female index cases respectively). In female patients, HBe Ag positively affected the transmission rate (49% vs. 23.4%). There was a dominant change in transmission rate of female patients with negative results for Hbe Ag with HDV coinfection, where the transmission rate changed from 25% in patients with negative results for HDV Ab to 5% in those with positive results. In Hbe Ag negative male index cases, the transmission rate was 1.3% in cases with positive results for HDV Ab compared to 7% in those with negative findings. The overall transmission rate was statistically different between patients with positive and negative results for HDV Ab (P = 0.016). Conclusions: There is a minor but consistent pattern change in the presence of HDV infection which reduces familial transmission of HBV, especially in female patients with negative results for HBe Ag. | en |
| DOI | https://doi.org/10.5812/hepatmon.7652 | en |
| Keyword | Data Mining | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Hepatitis D | en |
| Keyword | Machine Learning | en |
| Publisher | Brieflands | en |
| Title | Lower Intrafamilial Transmission Rate of Hepatitis B in Patients With Hepatitis D Coinfection: A Data-Mining Approach | en |
| Type | Research Article | en |
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