Delayed Graft Function and Acute Rejection in Kidney Transplant Patients with Positive Panel-Reactive Antibody and Negative Donor-Specific Antibodies
| Author | Ha Nguyen Thi Thu | en |
| Author | Manh Bui Van | en |
| Author | Dung Nguyen Thi Thuy | en |
| Author | Kien Truong Quy | en |
| Author | Duc Nguyen Van | en |
| Author | Van Diem Thi | en |
| Author | Ha Do Manh | en |
| Author | Dai Do Khac | en |
| Author | Dung Nguyen Dang | en |
| Author | Quyet Do | en |
| Author | Toan Pham Quoc | en |
| Author | Thang Le Viet | en |
| Issued Date | 2020-11-30 | en |
| Abstract | Background: Delayed graft function (DGF) and acute rejection (AR) are common complications in kidney transplant patients. Objectives: The study evaluated DGF and AR in highly sensitized patients and their effects on kidney function for six months post-transplantation. Methods: We enrolled 95 patients with kidney transplants from living donors who were divided into two groups. Group 1 included 47 highly sensitized patients with panel reactive antibody (PRA) < 20.0% and negative donor-specific antigen, and group 2 included 48 patients with negative PRA. All patients were followed for the state of DGF, AR, and kidney function for six months. Results: Group 1 showed a significantly higher proportion of DGF and AR than group 2 (27.7% versus 2.1%, P < 0.001 and 14.9% versus 2.1%, P = 0.031, respectively). The rates of positive PRA in DGF and AR patients were significantly higher than those in non-DGF and non-AR patients (92.9% versus 42.0%, P < 0.001 and 87.5% versus 46.0%, P = 0.031, respectively). Transplanted kidney function was significantly worse in patients with PRA and DGF and/or AR than in patients with negative PRA and non-DGF and non-AR only in the seventh-day post-transplantation. Conclusions: Kidney transplant in highly sensitized patients with positive PRA was related to the increased ratio of DGF and AR. | en |
| DOI | https://doi.org/10.5812/numonthly.107969 | en |
| Keyword | Delayed Graft Function | en |
| Keyword | Graft Rejection | en |
| Keyword | HLA Antigens | en |
| Publisher | Brieflands | en |
| Title | Delayed Graft Function and Acute Rejection in Kidney Transplant Patients with Positive Panel-Reactive Antibody and Negative Donor-Specific Antibodies | en |
| Type | Research Article | en |
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