Effects of Acarbose in Metabolic Control of Patients with Type 1 Diabetes Mellitus
| Author | F Sharifi | en |
| Author | M Ghazi Saidi | en |
| Author | N Mousavi Nasab | en |
| Issued Date | 2008-01-31 | en |
| Abstract | A carbose is a reversible inhibitor of the intestinal alpha-glucosidases, the oral administration of which delays absorption of carbohydrates. The aim of this study was to investigate the effect of administration of acarbose on parameters of gly-caemic control, lipid parameters and tolerability in ambulant type 1 diabetic subjects. Materials and Methods: Entry criteria included being: diabetic, age below 30 years and a history of at least one episode of diabetic ketoacidosis insufficiently controlled with diet and insulin. The data of 17 patients (6 men and 11 women, mean age 17.2±3.5 (range 14–26) years, median duration of diabetes 8 (range 1–20) years were valid for statistical analysis. Results: During the run-in period HbA1c levels tended to decrease from 9.5±1.1 to 9±1.7%. After 12 weeks of acarbose treatment, the mean level had decreased further to 7.6±1.6% (P: 0.002). Af-ter discontionuing acarbose, HbA1c levels in-creased to a mean level of 8.8±0.9%. A significant reduction in Fasting Plasma Glucose (FPG) (from 195±62 to 139±73 mg/dL, P | en |
| DOI | https://doi.org/ | en |
| Keyword | Type 1 diabetes | en |
| Keyword | Glycemic control | en |
| Keyword | Acarbose | en |
| Keyword | Alpha glucosidase inhibitors | en |
| Publisher | Brieflands | en |
| Title | Effects of Acarbose in Metabolic Control of Patients with Type 1 Diabetes Mellitus | en |
| Type | Research Article | en |
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