International Journal of Endocrinology and Metabolism

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The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.

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Optimal Cut-off Points of the Standardized Continuous Metabolic Syndrome Severity Score (cMetS-S) for Predicting Cardiovascular Disease (CVD) and CVD Mortality in the Tehran Lipid and Glucose Study (TLGS)
(Brieflands, 2024-10-31) Maryam Adib; Ladan Mehran; Safdar Masoumi; Iman Vatanpoor; Fereidoun Azizi; Atieh Amouzegar
Background: Metabolic Syndrome (MetS) is a prevalent condition associated with an increased risk of cardiovascular disease (CVD) and CVD mortality. Due to the limited clinical applicability of MetS, the standardized continuous metabolic syndrome severity score (cMetS-S) has the potential to provide continuous assessment of metabolic risk. Objectives: This study evaluated the optimal cMetS-S cut-off points in the Tehran lipid and glucose study (TLGS) for predicting CVD and CVD mortality. Methods: The study included 7,776 participants over 30 years old at baseline, followed for 18 years. Sex-specific sensitivity (SS) and specificity (SP) of cMetS-S measures for predicting CVD and CVD mortality were evaluated using a receiver operating characteristic (ROC) curve, along with the area under the curve (AUC), employing a naive estimator and considering event failure status and MetS variables. Results: The cut-off point of cMetS-S for CVD was 0.13 (SS: 65.5%, SP: 59.6%) for the total population, 0.44 (SS: 49.6%, SP: 68.1%) for males, and 0.27 (SS: 64.2%, SP: 69.2%) for females. The cut-off point of cMetS-S for CVD mortality was 0.53 (SS: 51.3%, SP: 71.9%) for the total population, 0.76 (SS: 35.1%, SP: 76.2%) for males, and 0.28 (SS: 78.8%, SP: 66.4%) for females. The AUC (95% CI) of MetS based on the International Diabetes Federation (IDF) and Joint Interim Statement (JIS) definitions were 60.0 (65.3 - 56.8) and 61.1 (59.6 - 56.8) for CVD, and 59.3 (56.0 - 62.5) and 59.4 (56.3 - 62.6) for CVD mortality. Conclusions: The cut-off points of cMetS-S for CVD and CVD mortality differ between men and women. The cMetS-S could be a better predictive tool for CVD and CVD mortality than MetS.
Legacy of the Tehran Obesity Treatment Study: Findings from 10 Years Bariatric Surgery Survey
(Brieflands, 2024-10-31) Behnaz Abiri; Minoo Heidari Almasi; Farhad Hosseinpanah; Danial Molavizadeh; Alireza Khalaj; Maryam Mahdavi; Majid Valizadeh; Maryam Barzin
Context: This paper aims to review the findings of the Tehran Obesity Treatment Study (TOTS) on obesity and bariatric surgery (BS). Evidence Acquisition: The objective of this review is to assess all aspects of BS in individuals with severe obesity, focusing on research conducted within the TOTS framework. Results and Conclusions: The TOTS studies have produced significant national-level findings, highlighting critical issues related to the effectiveness and outcomes of bariatric procedures, the importance of comprehensive nutritional management, and the complications associated with these interventions in this population.
The Effect of High Protein-High Fat and High Protein-High Carbohydrate Meals on Resting Metabolic Rate and Metabolic Factors in Overweight and Obese Adults: The Study Protocol for a Randomized Crossover Clinical Trial
(Brieflands, 2024-10-31) Saber Sahebi; Mohsen Nematy; Fatemeh Sadat Hashemi Javaheri; Lida Jarahi; Mohammad Safarian; Zahra Valeh
Background: The macronutrient composition of daily meals plays a crucial role in influencing the body's metabolic responses during the postprandial phase. However, existing research on the effects of macronutrients, particularly fats and carbohydrates, has produced inconsistent findings. Objectives: This study aims to evaluate the postprandial effects of two high-protein meals—one low in fat and high in carbohydrates (HP-LF-HC) and the other high in fat and low in carbohydrates (HP-HF-LC)—on energy metabolism, appetite response, and blood markers in overweight and obese men and women without underlying health conditions. Methods: This study will be conducted as an acute randomized crossover clinical trial at the Health Monitoring Center of Mashhad University of Medical Sciences (MUMS) within Imam Reza Hospital, Mashhad, Iran. A total of 30 overweight and obese men and women, meeting the eligibility criteria and free of underlying diseases, will be recruited through a public call. Participants will be randomly assigned to receive both intervention meals, with a washout period of at least one week between each trial. Results: The primary outcomes will focus on the acute effects of the two dietary interventions on energy metabolism, particularly resting metabolic rate (RMR), and appetite response. Secondary outcomes will include changes in lipid profiles, insulin, blood glucose levels, thyroid hormones, and epinephrine. Conclusions: This study aims to identify which macronutrient composition most effectively enhances resting energy expenditure. The findings could provide valuable insights for dietitians in developing more efficient dietary plans, helping overweight and obese individuals maintain an ideal weight or achieve weight loss by modifying food composition without altering meal volume.
Positive Interference in Triiodothyronine (T3) Assay Using a Radioimmunoassay Kit
(Brieflands, 2007-10-31) N Rezaei-Ghaleh; M Hedayati; A Ordookhani; F Azizi
Determination of thyrotropin (TSH), total and free thyroxine (T4) and triiodothyronine (T3) are widely used for thyroid function evaluation. There have been numerous reports of interfer-ence in thyroid hormone immunoassays. Herein, the possible occurrence of interference is inves-tigated for a radioimmunoassay kit of total T3. Materials and Methods: A total of 3471 patients were examined through the serum level meas-urement of TSH, total T4 and T3. T3 analysis was made through a competitive solid-phase radio labeled (125I) immunoassay by T3 Izotop kit (Izotop Co. Budapest, Hungary). The presence of T3 assay interference was considered probable if the endocrine profile was inconsistent with the clinical picture and/or the obtained value for T3 showed extreme deviaton from normal levels, i.e. above 780 ng/dL. For such patients, the exis-tence of interference was verified by re-measuring T3 level by another RIA kit (Immu-notech kit, Marseille, France). Results: Among 3471 patients studied, 40 cases (1.2 %) had spuriously high T3 serum levels with T3-Izotop kit while normal T3 levels (132.1±31.0 ng/dL) were observed with T3-Immunotech kit; the positive interference was more prevalent among women (1.4% vs. 0.5% in men), especially post-menopausal women. Mean serum levels of total T4 and TSH in the positive interference group were 9.0±2.0 μg/dL and 1.79±1.47 μU/mL, respectively. Conclusion: In accordance with numerous re-ports of interferences in thyroid hormone im-munoassays, the results of our study indicates that both laboratory professionals and clinicians must be vigilant to the possibility of antibody interference in thyroid function assays.
Thyroid, Parathyroid and Gonadal Function, and Glucose Tolerance After Bone Marrow Transplantation and Chemotherapy
(Brieflands, 2003-01-31) M Khoshnyat; B Larijani; A Ghavamzadeh; b Bahar; O Tabatabaei
: Following bone marrow transplantation (BMT), life expectancy of many patients increases, necessitating medical follow up, especially function of the endocrine gland. Previous studies have shown that endocrine dysfunctions are caused not only by total body irradiation, but also by cytotoxic conditioning regimens.Materials and Methods: 46 patients (12 F, 34 M), aged 1.5-49 years were evaluated for thyroid (T3, T4, TSH, T3RU, FTI, Anti Tg-Ab, Anti TPO-Ab), parathyroid (Ca, Alkp, PTH), gonad function (LH, FSH, E2, progesterone in females and semen analysis in males) and function of β-cells of pancreas by O.G.T.T (in 12 major thalassemic patients) before and 3, 6, 12, 24 months after BMT, by the “Little” Busulfan-Cyclophosphamide conditioning regimen.Results: There are no differences between results of clinical examinations and laboratory tests of pre and post BMT function of thyroid or parathyroid and calcium metabolism. The function of leydig cells was normal in 11 adult men (G5P5) before and 3, 6, 12 months after BMT, but injury of germinal cells (oligo- or azospermia) before and 12 months after BMT was seen. There is no relation between FSH and injury of germinal cells. Development of puberty was normal in 5 boys (G2P2 or G3P3) before and one year after BMT Primary hypogonadism was induced in 4 females (B5P5) after BMT In one 14 year-old female, regular menstruation continued 2 years after BMT In one girl (P1B1 before BMT) ovarian failure developed 12 months after BMT. Function of β- cells in thalassemic patients (Ferritin>1000 before BMT) before and after BMT was normal.Conclusion: One year after B.M.T, the chemotherapy-conditioning regimen per se did not affect function of thyroid or parathyroid gland, but ovarian failure and germinal cells injuries developed (without effect on leydig cells). BMT had no effect on the function of β- cells of the pancreas.
Remission Rate of Graves' Disease and the Trend of Changes in Serum TSH Receptor Antibodies in Prolonged Antithyroid Drug Treatment
(Brieflands, 2020-06-30) Danilo Villagelin; Roberto Bernardo Santos; João Hamilton Romaldini
Context: Graves’ disease is an autoimmune disease caused by thyrotropin receptor antibodies (TRAb). These antibodies can be measured and used for the diagnosis, prediction of remission, and risk of Graves’ orbitopathy development. There are three treatments for Graves’ disease that have remained unchanged for the last 75 years: Antithyroid drugs, radioiodine, and surgery. Antithyroid drugs are the first treatment option worldwide and are usually used for 12 - 18 months. Recent reports suggest the use of antithyroid drugs for more than 18 months with better outcomes. This review focuses on two aspects of treatment with antithyroid drugs: The impact of using antithyroid drugs for more than 12 - 18 months on remission rates and the trend of TRAb during prolonged antithyroid drug treatment. Evidence Acquisition: A review was performed in Medline on the published work regarding the duration of ATD treatment and remission of Graves' disease and also ATD treatment and TRAb status during the 1990 - 2019 period. Results: Remission rates are variable (30% - 80%), and many clinical and genetic factors serve as predictors. The long-term use of antithyroid drugs appears to increase remission rates. TRAb values usually decline during ATD treatment, but the trend could occur in two ways: Becoming negative or showing a fluctuating pattern. However, approximately 10% of the patients will remain TRAb-positive after five years of treatment with antithyroid drugs. Conclusions: Antithyroid drugs can be used for long periods with an increase in remission rates, and a gradual decrease in TRAb levels, with the disappearance of TRAb in 90% of the patients after 60 months.
Islamic Fasting and Thyroid Hormones
(Brieflands, 2015-04-01) Fereidoun Azizi
This article does not have an abstract.
Assessment of Influencing Factors on Outcome of Transsphenoidal Surgery in Acromegalic Patients
(Brieflands, 2011-10-31) Zohreh Annabestani; Mohammad Reza Mohajeri-Tehrani; Ozra TabatabaieMalazy; Shahrzad Mohseni; Ramin Heshmat; Mohammad Karim Shahrzad; Bagher Larijani
Background: Transsphenoidal surgery (TSS) is the most effective treatment for acromegalic patients, and two major factors that have been suggested as useful predictors in assessing this therapy’s success are: tumor size and preoperative basal growth hormone (GH) levels.Objectives: The aim of this study was to illustrate the relationship between some predictor factors and transsphenoidal surgery (TSS) outcomes and its remission rate.Patients and Methods: A total of 20 patients underwent TSS by 4 neurosurgeons in 4 university hospitals in Tehran and were followed up for 1 year. An oral glucose tolerance test was performed at 1 week after surgery and then 3, 6, and 12 months after surgery. Moreover, Insulin Growth Factor- 1 (IGF-1) was measured at 6 and 12 months after surgery.Results: Initial remission was observed in 7 (35%) patients with a recurrence rate of 10%. The nonresponse rate was 55%. The analysis showed a significant relationship between IGF-1 and surgery outcome in the cured patients at 6 months after surgery (P = 0.005). No significant statistical relationship was found between tumor size and the TSS outcome (P = 0.696).Conclusions: Given the high failure and recurrence rates following TSS in Iran, it seems important to pay more attention to diagnosing the disease earlier and improving surgical methods. Implication for health policy/practice/research/medical education:Recurrence rate of acromegaly after TSS is fairly high in Iran. It may be due to latency of diagnosis and loss of patient follow up after surgery. Therefore practitioners should be more pay attention to these patients after surgery. Please cite this paper as:Annabestani Z, Mohajeri-Tehrani MR, Tabatabaie–Malazy O, Mohseni S, Heshmat R , Shahrzad MK, et al. Assessment of Influencing Factors on Outcomes of Transsphenoidal Surgery in Acromegalic Patients. Int J Endocrinol Metab. 2011;9(4):360-3. DOI: 10.5812/Kowsar.1726913X.2125 Copyright © 2011 Kowsar M. P. Co. All rights reserved.
The Effect of Volume of Consumed Water on Drinking-Induced Sweating and Plasma Levels of Arginine Vasopressin, Epinephrine and Norepinephrine
(Brieflands, 2004-01-31) Khamnei S; Hosseinlou A; Ibrahimi H
The purpose of this study was to investigate the effect of the volume of consumed water on the sweating response and plasma levels of arginine vasopressin, epinephrine and norepinephrine in the first few minutes of drinking.Materials and Methods: After 4 hours water deprivation, six healthy male medical students were exposed to heat and performed mild exercise under an ambient temperature (2 hours, 38-40°C, relative humidity
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia
(Brieflands, 2017-01-31) Laura Ohana Marques Coelho de Carvalho; Raymundo Miguel Garcia Lora; Claudia Renata Rezende Penna; Izabel Calland Ricarte Beserra
Background: Testicular adrenal rest tumors are a benign condition characterized by the presence of remnants of adrenal tissue within the testes that can lead to infertility. Testicular microlithiasis are calculus deposits within the seminiferous tubules. Both are described in congenital adrenal hyperplasia. Objectives: Describe the frequency of testicular adrenal rest tumors and testicular microlithiasis in a Brazilian case series of patients with classic congenital adrenal hyperplasia and to also relate these changes to disease control and hypothalamic-pituitary-gonadal axis disorders. Methods: Case series study. An ultrasound examination of the scrotum was performed on 12 patients between the ages of 5.33 to 22 (14.72 ± 5.26) years. Testicular adrenal rest tumors were classified according to the degree of testicular infiltration in stages by adapting the Grinten’s classification, ranging from the absence of testicular adrenal rests visible by ultrasound (stage ≤ 1) to chronic obstruction of the testicular parenchyma with irreversible damage of the testicle (stage 5). Results: Six patients (5 salt wasting and 1 simple virilizing) with an average age of 17.27 ± 3.09 years and have gone through puberty showed testicular adrenal rest tumors (Grinten stage ≥ 3). In 2 of the patients there was a coincidence with testicular microlithiasis. The frequency of testicular adrenal rest tumors did not relate with the levels of serum 17-hydroxyprogesterone and androstenedione. In 3 patients with testicular adrenal rest tumors, gonadotropin levels were suggestive of hypergonadotropic hypogonadism and one of hypogonadotropic hypogonadism. Conclusions: Testicular adrenal rest tumors were found in greater frequency during puberty and was not related to hormonal control in this group. Some of them happened with testicular microlithiasis.
Safety of Raloxifene in Hemodialysis Patients
(Brieflands, 2012-09-01) Didy Jacobsen
This article does not have an abstract.
Spontaneous ovarian hyperstimulation in pregnant women with hypothyroidism
(Brieflands, 2006-10-31) S Borna; A? Nasery
Spontaneous hyperstimulations syndrome had been reported in women with hypothyroidism, and polycysticovary syndrome. This report describesa case in which a naturally conceived pregnancy was associated with spontaneous ovarian hyper stimulation and hypothyroidism.1-4We treated our case by levothyroxine. Within 2 weeks a remarkable improvement was observed, with resolution of ascites and decrease in serum TSH level. The hormonal tests for thyroid function were normal 3 months after treatment. Pregnancy was allowed to proceed under close maternal and fetal surveillance. The mother’s progress was then followed at normal antenatal check-ups and no serious complications developed. Ten weeks after delivery ovarian cysts regressed completely. Thyroid hormone replacement seems to be the best therapeutic approach, but in some patients the complete resolution of the ovarian cysts does not take place after being euthyroid.has been extensively described after treatment with exogenous gonadotropins, clomiphene citrate, and gonadotropin releasing hormone. OHSS, not related to ovulation induction is rare. Spontaneous hyperstimulation syndrome has been reported in women with hypothyroidism, polycystic ovary syndrome and pregnancy), gonadotroph pituitary adenoma, and normal pregnancy.1-4This report describes a case in which a naturally conceived pregnancy is associated with spontaneous ovarian hyper stimulation and hypothyroidism.
Association of Insulinoma and Type 2 Diabetes Mellitus
(Brieflands, 2017-01-31) Hassan Ouleghzal; Tarik Ziadi; Mohammed Menfaa; Soumia Safi
The association of diabetes mellitus and insulinoma is unusual. We are reporting the case of a 58 years old patient having diabetes mellitus type 2 for several years. This patient was well balanced with oral anti-diabetic treatment. However, the diagnosis of insulinoma was discussed due to recent episodes of hypoglycemia that persisted even after stopping the treatment. Abdominal CT allowed the topographic diagnosis. The patient underwent a caudal pancreatectomy. Furthermore, the postoperative period shows that the diabetes mellitus requires the oral anti-diabetic treatment and basal insulin have to be stable. Then, the occurrence of hypoglycemia in the diabetic mellitus type 2 and, especially the persistence after discontinuation of therapy, suggest the unusual diagnosis of insulinoma as illustrated in our observation.
Transient diabetes insipidus in a woman with a twin pregnancy: A case report
(Brieflands, 2010-04-30) Zahra Abbasi Ranjbar; Amir Bahrami; Farzad Najafipoor; Majid Mobassery
Transient diabetes insipidus (DI), a rare complication of pregnancy, results from excessive activity of placental vasopressinase. If unrecognized, it may threaten the life of both mother and fetus. Here we report a case of 33 year-old women with a twin pregnancy and transient diabetes insipidus, believed to be due to increased vasopressin degradation rate. The purpose of this case report is to reassess gestational DI and to discuss its appropriate management. c 2011 Kowsar M.P.Co. All rights reserved. Please cite this paper as:Abbasi Ranjbar Z, Bahrami A , Najafipoor F, Mobassery M. Transient diabetes insipidus in a woman with a twin pregnancy: A case report. Int J Endocrinol Metab.2010;8(2):94-96.
Effects of Acarbose in Metabolic Control of Patients with Type 1 Diabetes Mellitus
(Brieflands, 2008-01-31) F Sharifi; M Ghazi Saidi; N Mousavi Nasab
A carbose is a reversible inhibitor of the intestinal alpha-glucosidases, the oral administration of which delays absorption of carbohydrates. The aim of this study was to investigate the effect of administration of acarbose on parameters of gly-caemic control, lipid parameters and tolerability in ambulant type 1 diabetic subjects. Materials and Methods: Entry criteria included being: diabetic, age below 30 years and a history of at least one episode of diabetic ketoacidosis insufficiently controlled with diet and insulin. The data of 17 patients (6 men and 11 women, mean age 17.2±3.5 (range 14–26) years, median duration of diabetes 8 (range 1–20) years were valid for statistical analysis. Results: During the run-in period HbA1c levels tended to decrease from 9.5±1.1 to 9±1.7%. After 12 weeks of acarbose treatment, the mean level had decreased further to 7.6±1.6% (P: 0.002). Af-ter discontionuing acarbose, HbA1c levels in-creased to a mean level of 8.8±0.9%. A significant reduction in Fasting Plasma Glucose (FPG) (from 195±62 to 139±73 mg/dL, P
Female Pattern Hair Loss
(Brieflands, 2013-10-01) Ingrid Herskovitz; Antonella Tosti
Context:: Female pattern hair loss (FPHL) also known as female androgenetic alopecia is a common condition afflicting millions of women that can be cosmetically disrupting. Prompt diagnosis and treatment are essential for obtaining optimal outcome. Evidence Acquisition:: A) Diffuse thinning of the crown region with preservation of the frontal hairline (Ludwig’s type) Results:: The most important diseases to consider in the differential diagnosis of FPHL include Chronic Telogen Effluvium (CTE), Permanent Alopecia after Chemotherapy (PAC), Alopecia Areata Incognito (AAI) and Frontal Fibrosing Alopecia (FFA). This review describes criteria for distinguishing these conditions from FPHL. Conclusions:: The only approved treatment for FPHL, which is 2% topical Minoxidil, should be applied at the dosage of 1ml twice day for a minimum period of 12 months. This review will discuss off-label alternative modalities of treatment including 5-alfa reductase inhibitors, antiandrogens, estrogens, prostaglandin analogs, lasers, light treatments and hair transplantation.
Association of Mean Platelet Volume With Androgens and Insulin Resistance in Nonobese Patients With Polycystic Ovary Syndrome
(Brieflands, 2014-10-01) Bercem Aycicek Dogan; Ayse Arduc; Mazhar Muslum Tuna; Ersen Karakılıc; Iffet Dagdelen; Yasemin Tutuncu; Dilek Berker; Serdar Guler
Background: Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies. Objectives: This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS). Patients and Methods: A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m2 (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m2 (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment. Results: No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively; P = 0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P > 0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P = 0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P = 0.016, r = -0.229; and P = 0.006, r = -0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations. Conclusions: Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.
Can Body Weight Reduction in Obese Children Improve Attention Deficit Hyperactivity Disorder Symptoms in the Short Term? Clinical and Research Implications
(Brieflands, 2011-01-31) Ahmad Ghanizadeh
This article does not have abstract.
The Principles of Biomedical Scientific Writing: Abstract and Keywords
(Brieflands, 2020-01-31) Zahra Bahadoran; Parvin Mirmiran; Khosrow Kashfi; Asghar Ghasemi
An abstract is a self-contained, short, powerful statement that describes a larger body of work. It may be incorporated as part of a published paper, book, grant proposal, thesis, research report, or a conference paper. An abstract of a scientific paper will be published online independently, so it should make sense when it is read alone. An abstract of a hypothesis-testing paper consists of at least four key elements, as follows: (1) study question/hypothesis/aim, (2) experiments/material and methods, (3) results, and (4) response to the question/conclusion(s). The abstract usually begins with a background and may end in applications, recommendations, implications, or speculations. The abstract is one of the many features of a manuscript that competes for the readers’ attention; therefore, it should be informative, accurate, attractive, and concise. Since a huge amount of work must be compressed into a few sentences, writing an abstract may be a difficult task that needs professional skills. Here, we provide a practical guide to writing an abstract and selecting keywords for a hypothesis-testing medical paper.
The Experience of Women Affected by Polycystic Ovary Syndrome: A Qualitative Study From Iran
(Brieflands, 2014-04-01) Fatemeh Nasiri Amiri; Fahimeh Ramezani Tehrani; Masoumeh Simbar; Ali Montazeri; Reza Ali Mohammadpour Thamtan
Background:: Polycystic ovary syndrome (PCOS) is the most common chronic endocrine disorder. It has significant and diverse clinical consequences including reproductive, metabolic, and psychological morbidities as well as predisposition to malignancies. It is unclear how women with PCOS experience symptoms of this syndrome. Objectives:: The aim of this study was to clarify the dimensions and components of quality of life in iranian women with PCOS. Patients and Methods:: This study was a qualitative study to explore and document perceptions of women with PCOS about their disorder and quality of life. Semi-structured interviews with open ended questions were conducted with 23 women with PCOS. The interviews were continued to reach data saturation. The study was conducted in the Reproductive Endocrinology Research Center of Shahid Beheshti University of Medical Sciences. All the interviews were recorded and transcribed. Constant comparative analysis of the data was conducted manually according to the Strauss and Corbin analysis method. Results:: The study revealed that the most important factors affecting quality of life in women with PCOS were the role functioning items as well as physical, mental, emotional, cognitive, and social dimensions. Conclusions:: Comprehensive cares concerning various mental, emotional, cognitive, and social dimensions of quality of life should be planned for women with PCOS.

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