Effects of aging on Cholinergic system of rat isolated ileum
| Author | R Mortazavi | en |
| Author | F Derakhshan | en |
| Issued Date | 2000-03-31 | en |
| Abstract | Background: Aging is associated with changes in gastrointestinal functions. Objective: To determine the effects of aging on the cholinergic system of rat isolated ileum. Methods: In this research, isolated ileum from 9 to 11 days, 2 months, 6 months, and one year old male albino rats (N?6) were prepared and their contraction responses were characterized by determining the ED50 of acetylcholine. Findings: According to results, the sensitivity of m-AchRs were decreased in relation to age (The ED50 of acetylcholine in 9-11 days, 2 months, 6 months, and 1 year old rats were 3.46×10^-5, 6.58×10^-5, 1.34×10^-5 and 1.018×10^-4 respectively). The maximum response was observed in 6 months old rats. Conclusion: The decline of responsiveness appears to be the result of age-related changes in cholinergic neuromuscular transmission. | en |
| DOI | https://doi.org/ | en |
| Keyword | Aging | en |
| Keyword | Cholinergic | en |
| Keyword | Rat | en |
| Keyword | Ileum | en |
| Publisher | Brieflands | en |
| Title | Effects of aging on Cholinergic system of rat isolated ileum | en |
| Type | Research Article | en |