Evaluation of Chemokines and Cytokines as Biomarkers for Disease Severity in COVID-19-Infected Patients
| Author | Rosa Karimi | en |
| Author | Abdolreza Mohamadnia | en |
| Author | Farzaneh Hosseini | en |
| Author | Naghmeh Bahrami | en |
| Author | Hamidreza Jamaati | en |
| Orcid | Rosa Karimi [0009-0006-1009-6183] | en |
| Orcid | Abdolreza Mohamadnia [0000-0002-9960-8854] | en |
| Orcid | Naghmeh Bahrami [0000-0002-3575-4094] | en |
| Orcid | Hamidreza Jamaati [0000-0002-5402-1531] | en |
| Issued Date | 2024-01-31 | en |
| Abstract | Background: Alterations in cytokine and chemokine levels during SARS-CoV-2 infection may serve as indicators of disease severity. Objectives: This study aimed to evaluate the levels of plasma cytokines and chemokines in patients with COVID-19. Methods: The study included 120 COVID-19 patients, divided into severe, mild, and recovered categories (n = 40 for each group). Plasma levels of cytokines such as interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α) were measured using ELISA, while chemokines like monocyte chemoattractant protein 1 (MCP-1) and programmed death protein 1 (PD-1) were quantified through qRT-PCR. Results: A higher incidence of positive biomarkers IL-8, TNF-α, MCP-1, and PD-1 was observed in the severe group compared to the mild and recovered groups. Notably, the expression levels of PD-1 and MCP-1 were significantly elevated in severely infected individuals relative to those in healthy subjects. A strong positive correlation was also noted between PD-1 and MCP-1 levels in cases of severe infection. Conclusions: The findings suggest that MCP-1, PD-1, TNF-α, and IL-8 could act as biomarkers for assessing the severity of COVID-19 infections. These results aim to deepen our understanding of the immunopathological mechanisms at play in this disease. | en |
| DOI | https://doi.org/10.5812/jjm-143611 | en |
| URI | https://brieflands.com/journals/jjm/articles/143611 | en |
| Keyword | COVID-19 | en |
| Keyword | Cytokines | en |
| Keyword | Chemokines | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Chemokines and Cytokines as Biomarkers for Disease Severity in COVID-19-Infected Patients | en |
| Type | Research Article | en |
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