Serum Levels of Annexin A2 as a Candidate Biomarker for Hepatic Fibrosis in Patients With Chronic Hepatitis B
| Author | Servet Kolgelier | en |
| Author | Nazlim Aktug Demir | en |
| Author | Ahmet Cagkan Inkaya | en |
| Author | Sua Sumer | en |
| Author | Serap Ozcimen | en |
| Author | Lutfi Saltuk Demir | en |
| Author | Fatma Seher Pehlivan | en |
| Author | Mahmure Arslan | en |
| Author | Abdullah Arpaci | en |
| Issued Date | 2015-10-01 | en |
| Abstract | Background: Hepatologists have studied serologic markers of liver injury for decades. Annexins are a prominent group of such markers and annexin A2 (AnxA2) is one of the best characterized annexins. AnxA2 inhibits HBV polymerase among other functions. Its expression is up-regulated in regenerative hepatocytes. Objectives: To determine if serum AnxA2 level has a role in estimating liver damage in chronic HBV infection and investigate whether AnxA2 levels correlate with hepatic fibrosis. Patients and Methods: This study included 173 patients with chronic hepatitis B (CHB) and 51 healthy controls. Liver fibrosis was graded histologically on liver biopsy samples. Blood samples were taken from patients during biopsy and serum AnxA2 levels were measured with ELISA. Results: In a group of adult patients with CHB, AnxA2 values were far higher than those of the control group (P = 0.001). When we assessed AnxA2 levels based on fibrosis stages, serum AnxA2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; P = 0.001). Conclusions: AnxA2 is a useful biomarker for early stage fibrosis in patients with CHB. | en |
| DOI | https://doi.org/10.5812/hepatmon.30655 | en |
| Keyword | Annexin A2 | en |
| Keyword | Hepatitis B | en |
| Keyword | Chronic | en |
| Keyword | Liver Fibrosis | en |
| Keyword | Biological Marker | en |
| Publisher | Brieflands | en |
| Title | Serum Levels of Annexin A2 as a Candidate Biomarker for Hepatic Fibrosis in Patients With Chronic Hepatitis B | en |
| Type | Brief Report | en |
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