Wedelolactone from Vietnamese <i>Eclipta prostrata </i>(L) L<i>. </i>Protected Zymosan-induced shock in Mice

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AuthorTrinh Tat Cuongen
AuthorGiang Huy Diemen
AuthorTran Trung Doanen
AuthorNguyen Quang Huyen
AuthorNguyen Phuongen
AuthorHoang the Hungen
Issued Date2018-04-30en
AbstractWedelolactone is known to have biological activities such as anti-inflammation hepatitis, anti-hepatotoxic activity, and trypsin inhibitory effect. However, up to date, there has not been any deep study on the role of wedelolactone for zymosan-induced signaling pathways in the process of regulating the excessive inflammatory responses in host. Here, we demonstrated that wedelolactone plays an essential role for regulation of zymosan-induced inflammatory responses in murine bone marrow-derived macrophages (BMDMs). The zymosan-mediated secretion of tumor necrosis factor-α (TNF)-α), interleukin (IL)-6), and IL12p40 but not IL-10 in BMDMs was significantly inhibited by pre-treatment with wedelolactone (30 µg/mL, P < 0.001). Furthermore, zymosan-induced supreoxide generation, NADPH oxidase (P < 0.001), phosphorylation of p47phox in BMDMs were significantly reduced by pre-treatment of wedelolactone (30 µg/mL). Collectively, these data indicated that wedelolactone reduced zymosan-induced inflammatory responses. Moreover, in-vivo wedelolactone (30 mg/kg) was significantly rescued from zymosan-induced shock through inhibition of systemic inflammatory cytokine levels.en
DOIhttps://doi.org/10.22037/ijpr.2018.2193en
KeywordWedelolactoneen
Keywordzymosanen
Keywordsepsisen
KeywordInflammationen
KeywordReactive oxygen speciesen
PublisherBrieflandsen
TitleWedelolactone from Vietnamese <i>Eclipta prostrata </i>(L) L<i>. </i>Protected Zymosan-induced shock in Miceen
TypeOriginal Articleen

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