Effect of adding garlic extract to anti-helicobacter pylori treatment

Abstract

Background: Nowadays, helicobacter pylori (H. pylori) antibiotic resistance is increasing. Objective: The aim of this study was to determine the effect of adding garlic extract to the anti-helicobacter pylori treatment . Methods: This clinical trial was conducted in 71 patients with peptic ulcer referred to the Booali Sina hospital in Qazvin during 2012. The patients were randomly allocated to intervention (33) and control (38) groups. In control group, 1 g amoxicillin, 500mg clarithromycin and 40mg pantoprazole were administered twice daily for two weeks. In intervention group, one garlic soft gel including 500 mg garlic extract was added to the above treatment. Eradication of infection was confirmed with carbon 14 urea breath test four weeks after treatment . Findings: Eradication of H. pylori infection was successful in 53% of the patients in the control group, and 75% of the patients in the intervention group and the difference was statistically significant . Conclusion: With regards to the results and due to the increased infection eradication, adding the garlic extract to the treatment regimen against H. pylori infection is recommended. Citation: Hajiaghamohammadi AA, Miroliaee A, Samimi R, Zargar A, Gholami R. Effect of adding garlic extract on anti-Helicobacter pylori treatment. J Qazvin Univ Med Sci. 2015 19 (1): 11-16.