Evaluation of the Antimalarial Effect of <i>Ferulago angulata</i> (Schlecht.) Boiss. Extract and Suberosin Epoxide Against <i>Plasmodium berghei</i> in Comparison with Chloroquine Using <i>in-vivo</i> Test
| Author | Seyed Ebrahim Sajjadi | en |
| Author | Nader Pestechian | en |
| Author | Mahnaz Kazemi | en |
| Author | Mohammad-Ali Mohaghegh | en |
| Author | Ahmad Hosseini-Safa | en |
| Issued Date | 2016-07-31 | en |
| Abstract | Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to evaluate the in-vivo antimalarial activity of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide, using suarian mice. A rodent malaria parasite, Plasmodium berghei was used to inoculate healthy male Swiss Albino mice of age 6-8 weeks and weight 23-27 g. Hydro-alcoholic extract of F. angulata (20, 100, 300, 600 mg/Kg) and suberosin epoxide suspension (10, 30, 50, 100 mg/Kg) were administered subcutaneously. Parameters including percentage of parasitemia, suppression of parasitemia and mean survival time were determined using standard test such as peter٬s. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1894 | en |
| Keyword | <i>Ferulago angulate</i> | en |
| Keyword | Suberosin epoxide | en |
| Keyword | <i>Plasmodium berghei</i> | en |
| Keyword | <i>Antimalaria</i> | en |
| Publisher | Brieflands | en |
| Title | Evaluation of the Antimalarial Effect of <i>Ferulago angulata</i> (Schlecht.) Boiss. Extract and Suberosin Epoxide Against <i>Plasmodium berghei</i> in Comparison with Chloroquine Using <i>in-vivo</i> Test | en |
| Type | Original Article | en |