Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat
| Author | Feraidoon Negahdar | en |
| Author | Mehdi Mehdizadeh | en |
| Author | Mohammad Taghi Joghataei | en |
| Author | Mehrdad Roghani | en |
| Author | Fereshteh Mehraeen | en |
| Author | Ehsan Poorghayoomi | en |
| Issued Date | 2015-10-31 | en |
| Abstract | Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretreatment could attenuate behavioral and neuronal derangement in 6-hydroxydopamine (6-OHDA)-induced model of PD in the rat. Unilateral intrastriatal 6-OHDA-lesioned rats received BBR at doses of 25 and/or 50 mg/kg (i.p.) three times at an interval of 24 h, started 2 days before the surgery. After 1 week, apomorphine caused significant contralateral rotations and a significant reduction in the number of Nissl-stained and tyrosine-hydroxylase (TH)-positive neurons on the left side of the substantianigra. BBR pretreatment at a dose of 50 mg/kg significantly reduced rotations and prevented loss of TH-positive neurons. These results indicate pre-lesion administration of BBR could protect against 6-OHDA toxicity and this may be of benefit besides other available therapies in PD. | en |
| DOI | https://doi.org/10.22037/ijpr.2015.1756 | en |
| Keyword | Berberine | en |
| Keyword | Parkinson’s disease | en |
| Keyword | 6-hydroxydopamine | en |
| Keyword | Tyrosine hydroxylase | en |
| Publisher | Brieflands | en |
| Title | Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat | en |
| Type | Original Article | en |
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