Induced HBs antigenemia in healthy adults after immunization with two different hepatitis B recombinant vaccines
| Author | Masoud Ziaee | en |
| Author | Alireza Saadatjoo | en |
| Author | Malihe Mohamadpour | en |
| Author | Mohammad Hasan Namaei | en |
| Orcid | Mohammad Hasan Namaei [0000-0003-2889-8273] | en |
| Issued Date | 2010-12-31 | en |
| Abstract | Background and Aims: Currently, vaccination is the most effective protective tool against hepatitis B virus infection. Some studies have shown that positive results for a hepatitis B virus surface antigen (HBsAg) test may be seen after vaccination. The aim of this study was to compare the incidence of positive HBsAg results after vaccination with two different hepatitis B recombinant vaccines.Materials and Methods: In this clinical trial study, 62 healthy adult volunteers were randomly assigned to receive either the Engerix-B or the Hepavax-Gene hepatitis B recombinant vaccine. Blood samples were drawn 1, 3, and 5 days after vaccination and were tested for HBsAg using two different ELISA kits (Behring and Mega).Results: HBsAg was positive in 5, 3, and 2 participants of the Engerix-B group in the 1st, 3rd, and 5th days after vaccination, respectively, using the Behring ELISA kit; the test was positive in only one subject in the Hepavax-Gene group, on the 5th day after vaccination. No positive result was seen in any groups when the Mega ELISA kit was used to test the specimens. Conclusions: Our results showed transient HBsAg antigenemia after vaccination against hepatitis B. This condition depends on the type of vaccine and the HBsAg diagnostic test. | en |
| DOI | https://doi.org/ | en |
| Keyword | Hepatitis B vaccine | en |
| Keyword | Hepatitis B Surface Antigens | en |
| Publisher | Brieflands | en |
| Title | Induced HBs antigenemia in healthy adults after immunization with two different hepatitis B recombinant vaccines | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 69925-pdf.pdf
- Size:
- 756.78 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF