Clinical Usefulness of HBsAg Quantification in Patients with Chronic Hepatitis B Infection
| Author | Ergenekon Karagoz | en |
| Author | Alpaslan Tanoglu | en |
| Issued Date | 2017-04-30 | en |
| Abstract | Context: Quantitative hepatitis B surface antigen (qHBsAg) levels have been shown to assist the management of patients with chronic hepatitis B virus (HBV) infection and reflect the level of transcriptional activity of covalently closed circular DNA (cccDNA). It has been indicated the importance of co-operative use of qHBsAg and HBV-DNA for diagnosis and monitoring of CHB treatment. Evidence Acquisition: In order to achieve a comprehensive approach in HBsAg quantification, an extensive search was done using relevant keywords in major medical libraries to collect, categorize, and summarize data in different sections. Results: A combination of qHBsAg < 1000 IU/mL and HBV-DNA < 2000 IU/mL can identify inactive carriers. qHBsAg levels are changed during the natural history of HBV infection that progressively declines from the immune tolerance to the inactive phase. Conclusions: The use of qHBsAg in chronic hepatitis B (CHB) patients may bring about important complementary information regarding HBV DNA during treatment and help predict the treatment outcome. | en |
| DOI | https://doi.org/10.5812/hepatmon.36112 | en |
| Keyword | Hepatitis B Surface Antigen | en |
| Keyword | Chronic Hepatitis B Virus | en |
| Keyword | HBV DNA | en |
| Publisher | Brieflands | en |
| Title | Clinical Usefulness of HBsAg Quantification in Patients with Chronic Hepatitis B Infection | en |
| Type | Review Article | en |
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