Evaluating Liver Fibrosis by Transient Elastometry in Patients With HIV-HCV Coinfection and Monoinfection
| Author | Lucia Brescini | en |
| Author | Elena Orsetti | en |
| Author | Rosaria Gesuita | en |
| Author | Francesca Piraccini | en |
| Author | Elisa Marchionni | en |
| Author | Silvia Staffolani | en |
| Author | Pamela Castelli | en |
| Author | Davide Drenaggi | en |
| Author | Francesco Barchiesi | en |
| Issued Date | 2014-08-01 | en |
| Abstract | Background: Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. Objectives: The aim of this cross-sectional study was to identify factors associated with liver fibrosis (LF) in patients with HIV monoinfection and HIV-HCV coinfection. Patients and Methods: We analyzed LF by transient elastometry ([TE], Fibroscan) in three groups of patients (HIV, HIV-HCV and HCV) followed at the Infectious Diseases Department of University of Ancona, Italy, between October 2009 and November 2012. Results: In total, 354 adults including 98 HIV, 70 HIV-HCV and 186 HCV patients were studied. HIV-HCV patients had a longer duration of HIV (P < 0.006) and HCV (P < 0.001) infections. Additionally, they were receiving cART therapy for a longer period (P < 0.001); they had higher prevalence of lipodystrophy (P < 0.001) and higher HCV load (P = 0.004). LF was significantly more pronounced in HCV and HIV-HCV compared to HIV patients (P < 0.001). A total of 13.3%, 39.2% and 51.4% of HIV, HCV and HIV-HCV, respectively, showed a LF ≥ F2. Additionally, a severe LF (F = 4) was significantly more frequent among HIV-HCV compared to other groups. A longer exposure to didanosine, stavudine, lopinavir/ritonavir and fosamprenavir resulted in increased LF by univariate analysis (P ranging from < 0.001 to 0.007). By logistic regression analysis, the only variables significantly associated with increased LF were HCV coinfection, older age, and high AST values (P ranging from < 0.001 to 0.036). Conclusions: HCV coinfection, older age and AST were associated with LF in patients with HIV infection. | en |
| DOI | https://doi.org/10.5812/hepatmon.15426 | en |
| Keyword | Coinfection | en |
| Keyword | Liver Fibrosis | en |
| Keyword | Transient Elastometry | en |
| Publisher | Brieflands | en |
| Title | Evaluating Liver Fibrosis by Transient Elastometry in Patients With HIV-HCV Coinfection and Monoinfection | en |
| Type | Research Article | en |
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