Dermal Fibroblast Cells: Biology and Function in Skin Regeneration

Fibroblasts are mesenchymal cells, which play an important role in epithelial-mesenchymal reactions. These cells also play a key role in epidermal proliferation and differentiation and cellular matrix formation through secretion of different growth factors and cytokines. Cell therapy is a new treatment for skin diseases. In fact, conditions, such as burns, diabetic wounds, scars, and aging skin, have been treated with these cells. In cell therapy, samples obtained from the patient’s skin are isolated and cultured; then, the cells are injected into damaged tissues. In recent years, several clinical trials have been conducted in this area, and numerous studies have been published. In this review, we aimed to investigate the biology and function of these cells in the treatment of skin diseases.