Screening for Hepatocellular Carcinoma in Chronic Carriers of Hepatitis B and C in Markazi Province, Iran

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AuthorAli Fanien
AuthorIman Fanien
AuthorBabak Eshratien
AuthorParivash Samadianen
AuthorParisa Fanien
AuthorYaser Gorishien
AuthorFatemeh Mahdavianien
Issued Date2007-09-30en
AbstractBackground and Aims: Chronic HBV and HCV infections are known as important underlying causes of hepatocellular carcinoma (HCC). Their prevalence in Iran are estimated to be 1.7-5% and 0.5-1%, respectively. We investigated the prevalence of HCC in chronic carriers of HBV and HCV via alpha-feto protein (AFP) measurement and ultrasonography as well as pathological assessments. Methods: In this cross-sectional study, HBV and HCV positive cases were determined from documents in blood banks since 1985. From 1064 aviable cases, 514 were randomly selected and followed up for two consecutive years. For all patients, AFP testing and sonography were done after reconfirmation of chronicity. Cases with nodules or mass in sonography and AFP levels above 20 ng/ml were considered suspicious for HCC and after rechecking were referred for liver biopsy. Finally, HCC was confirmed pathologically.Results: The mean subjects' age was 35.19±13.16 years and hepatitis duration was 6.12±5.66 years. Twenty-nine (5.7%) had elevated AFP and 18 (3.5%) had nodules in sonogram. In 16 (3.13%) cases, HCC was detected pathologically. Risk of HCC was correlated with age >40 years, cirrhosis and hepatitis duration (Pen
DOIhttps://doi.org/en
KeywordHepatocellular Carcinomaen
KeywordHepatitis Ben
KeywordHepatitis Cen
KeywordAlpha-Feto Proteinen
PublisherBrieflandsen
TitleScreening for Hepatocellular Carcinoma in Chronic Carriers of Hepatitis B and C in Markazi Province, Iranen
TypeResearch Articleen

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