A Survey in the Basal Like Breast Carcinoma Phenotype in North East of Iran
| Author | Roham Salek | en |
| Author | Fatemeh Varshoee Tabrizi | en |
| Author | Kamran Ghaffarzadegan | en |
| Author | Golnaz Sabouri | en |
| Author | Azar Fanipakdel | en |
| Orcid | Azar Fanipakdel [0000-0003-4055-5783] | en |
| Issued Date | 2017-01-31 | en |
| Abstract | Background: Breast carcinoma is not a homogenous disease. It is divided into 5 pathological subtypes of luminal1, luminal2, strongly Her2 positive, basal like, and normal breast like. Basal like breast carcinoma that accounts for about 15% of all breast cancers has an aggressive clinical behavior with the features of high nuclear grade, negative estrogen receptor, progesterone receptor, and Her2 reactivity (triple negative). Objectives: We aimed at identifying the prevalence of basaloid phenotype among triple negative (TN) cases in our region via immunohistochemistry (IHC) staining using basaloid markers. Methods: We reviewed breast cancer patients in Omid and Imam Reza hospitals, Mashhad, Iran, between 2003 and 2007. We obtained the paraffin blocks from TN cases for immune-staining using cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14) and epidermal growth factor receptor1 (EGFR1) markers. Results: The incidence of TN disease among breast cancers was 21% (156/747). Based on IHC reactivity with at least one of the basaloid markers, from 59 available samples, 44 (75.4%) were basaloid. Conclusions: In our region, most triple negative tumors were basal like breast cancer (BLBC). Among these cases, most immune-reactivity was observed for EGFR1, followed by CK14 and CK5/6. | en |
| DOI | https://doi.org/10.17795/ijcp-4371 | en |
| Keyword | Breast Cancer | en |
| Keyword | Basal Like | en |
| Keyword | Triple Negative | en |
| Keyword | Immunohistochemistry | en |
| Keyword | Cytokeratin 5/6 | en |
| Keyword | Cytokeratin 14 | en |
| Keyword | EGFR1 | en |
| Publisher | Brieflands | en |
| Title | A Survey in the Basal Like Breast Carcinoma Phenotype in North East of Iran | en |
| Type | Research Article | en |
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